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Verapamil as a culprit of palbociclib toxicity.

Author: GowartyJasmine L, HerringtonJon D

Case ReportsIn the medical field, a report that describes in detail a unique case, an unusual medical condition, or the effect of a treatment. Provides new insights and possibilities for treatment through individual patient cases.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

This case report describes a patient who experienced adverse side effects while taking palbociclib and verapamil. The patient developed febrile neutropenia, grade 3 stomatitis, periorbital edema, and transaminitis. These side effects resolved upon discontinuation of verapamil, suggesting that verapamil's inhibition of both permeability-glycoprotein (P-gp) and CYP3A4 may have contributed to the adverse effects.
Paper Details　
Original Abstract of the Article :
A promising drug, palbociclib, received accelerated approval as a first line treatment when used with the aromatase inhibitor, letrozole, for postmenopausal women with hormone receptor positive advanced or metastatic breast cancer. We report a case of a patient who presented with febrile neutropenia...See full text at original site
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引用元：
https://doi.org/10.1177/1078155218761798

データ提供：米国国立医学図書館（NLM）

Verapamil: A Potential Culprit in Palbociclib Toxicity?

This case report explores a potential drug interaction between [palbociclib], a promising anti-cancer drug, and [verapamil], a calcium channel blocker. The authors describe a patient who experienced severe adverse effects while taking both medications.

A Complex Landscape of Drug Interactions

The patient presented with [febrile neutropenia, grade 3 stomatitis, periorbital edema, and transaminitis] while on palbociclib and verapamil. These adverse effects resolved upon discontinuation of verapamil, suggesting a potential interaction between the two drugs.

Navigating the Drug Interaction Desert

This case report highlights the complexity of drug interactions, emphasizing the importance of careful monitoring and awareness of potential interactions. Just as a camel must navigate a desert landscape with its diverse terrain, healthcare professionals must be mindful of the potential for drug interactions, ensuring patient safety and optimal treatment outcomes.

Dr. Camel's Conclusion

This case report serves as a reminder that the desert of drug interactions can be treacherous and unpredictable. Healthcare professionals must approach drug therapy with a cautious and vigilant mindset, carefully considering potential interactions and ensuring the safety of their patients.

Date :
  1. Date Completed 2019-04-24
  2. Date Revised 2019-04-24
Further Info :

Pubmed ID

29523051

DOI: Digital Object Identifier

10.1177/1078155218761798

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Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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