[Dihydropyrimidine dehydrogenase deficiency causes severe adverse effects of capecitabine].

The Hidden Dangers of Capecitabine: A Case Study of Dihydropyrimidine Dehydrogenase Deficiency

Capecitabine, a widely used chemotherapy drug, is a powerful weapon in the fight against cancer. However, this research highlights a rare but potentially life-threatening side effect: dihydropyrimidine dehydrogenase (DPD) deficiency. This case study tells the story of a 61-year-old man who experienced severe adverse effects after receiving capecitabine for adenocarcinoma of the gastroesophageal junction. This case highlights the critical importance of screening for DPD deficiency before administering capecitabine to patients.

Understanding the Risks of DPD Deficiency

The researchers discovered that the patient had extremely low levels of DPD protein, which is responsible for metabolizing 5-fluorouracil (FU), the active metabolite of capecitabine. This deficiency led to a buildup of FU, causing severe gastrointestinal toxicity, febrile neutropenia, and thrombocytopenia. The patient ultimately required a bowel resection due to hemorrhagic enteritis. This case emphasizes the need for routine testing for DPD deficiency to prevent such severe adverse events.

Navigating the Desert of Chemotherapy

This case study serves as a powerful reminder that even seemingly safe medications can have hidden risks. It's like encountering a hidden danger lurking in the desert of chemotherapy treatment. The research emphasizes the importance of careful patient selection and monitoring to minimize the risk of adverse events. It also underscores the need for ongoing research to develop safer and more effective treatment options for patients with cancer.

Dr.Camel's Conclusion

This case study highlights the importance of recognizing and managing DPD deficiency to ensure patient safety. It's like finding a hidden oasis of knowledge in the desert of chemotherapy treatment! By screening for this deficiency, we can better protect patients from severe side effects and ensure that they receive the most appropriate and effective treatment.