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Oxaliplatin Modulates the Characteristics of Voltage-Gated Calcium Channels and Action Potentials in Small Dorsal Root Ganglion Neurons of Rats.

Author: HagenackerTim, KleinschnitzChristoph, LeoMarkus, SchmittLinda-Isabell

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

Oxaliplatin, a drug used to treat colorectal cancer, can cause neurotoxicity in dorsal root ganglion (DRG) neurons. Short-term exposure to oxaliplatin reduced voltage-gated calcium channel (VGCC) currents in DRG neurons, while long-term exposure increased L- and T-type VGCC protein levels. These findings suggest that VGCCs are involved in oxaliplatin-mediated neurotoxicity.
Paper Details　
Original Abstract of the Article :
Oxaliplatin is important for treating colorectal cancer. Although oxaliplatin is highly effective, it has severe side effects, of which neurotoxicity in dorsal root ganglion (DRG) neurons is one of the most common. The key mechanisms of this neurotoxicity are still controversial. However, disturbanc...See full text at original site
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引用元：
https://doi.org/10.1007/s12035-018-1029-5

データ提供：米国国立医学図書館（NLM）

Oxaliplatin's Impact on Nerve Cells: A Desert of Neurotoxicity

Oxaliplatin, a powerful chemotherapy drug used to treat colorectal cancer, is like a desert sandstorm that can leave a trail of destruction in its wake. This study investigates the effects of oxaliplatin on nerve cells, exploring the mechanisms underlying oxaliplatin-induced neurotoxicity. The researchers focused on the impact of oxaliplatin on calcium channels in small dorsal root ganglion (DRG) neurons, which are crucial for transmitting pain signals.

Oxaliplatin's Devastating Effects: A Desert of Damaged Neurons

The study revealed that oxaliplatin significantly altered the function of calcium channels in DRG neurons, impacting the flow of calcium ions into the cells. It's like a desert sandstorm that disrupts the delicate balance of water and nutrients within a plant, leading to dysfunction. The researchers observed that oxaliplatin affected different types of calcium channels differently, suggesting a complex interplay between the drug and neuronal function.

Managing Oxaliplatin-Induced Neurotoxicity: A Desert of Research Opportunities

This research sheds light on the mechanisms underlying oxaliplatin-induced neurotoxicity, a common side effect of this important chemotherapy drug. It's like uncovering a hidden oasis in the desert, revealing new insights into the complex interplay between drugs and nerve cells. The study suggests that further research is needed to understand the precise mechanisms of oxaliplatin neurotoxicity and to develop strategies for preventing or mitigating this side effect.

Dr. Camel's Conclusion

This study unveils the intricate and often devastating effects of oxaliplatin on nerve cells. It's like exploring a desert landscape where the sandstorm has left a trail of destruction. The study highlights the importance of understanding the mechanisms behind oxaliplatin neurotoxicity, paving the way for future research and potentially leading to new strategies for managing this side effect.
Date :
  1. Date Completed 2019-01-18
  2. Date Revised 2021-01-09
Further Info :

Pubmed ID

29603093

DOI: Digital Object Identifier

10.1007/s12035-018-1029-5

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Languages

English

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