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Original Abstract of the Article :
The occurrence of drug induced liver injury (DILI) is the most common reason of post-marketing withdrawals. DILI in humans is difficult to predict using in vitro cytotoxicity screening and animal studies. A review of hepatotoxicity data was performed with the aim of identifying relevant factors that...See full text at original site
Dr.Camel's Paper Summary Blogラクダ博士について
ラクダ博士は、Health Journal が論文の内容を分かりやすく解説するために作成した架空のキャラクターです。
難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。
* ラクダ博士による解説は、あくまで論文の要点をまとめたものであり、原論文の完全な代替となるものではありません。詳細な内容については、必ず原論文をご参照ください。
* ラクダ博士は架空のキャラクターであり、実際の医学研究者や医療従事者とは一切関係がありません。
* 解説の内容は Health Journal が独自に解釈・作成したものであり、原論文の著者または出版社の見解を反映するものではありません。
引用元:
https://doi.org/10.1016/j.therap.2018.02.004
データ提供:米国国立医学図書館(NLM)
Drug-Induced Liver Injury: A Silent Threat in Drug Development
This study focuses on the critical issue of drug-induced liver injury (DILI), a serious side effect that can occur with certain medications. The researchers reviewed data on hepatotoxicity (liver toxicity) to understand the factors that might predict DILI and identify potential strategies for minimizing its occurrence.
The study highlights the challenge of predicting DILI in humans, as traditional methods like in vitro testing and animal studies often fail to capture the full complexity of liver toxicity. This is like navigating a desert with a map that doesn't accurately reflect the hidden dangers beneath the sand. It emphasizes the need for more sophisticated and predictive methods for assessing drug safety.
Improving Drug Safety
This study underscores the importance of careful drug development and monitoring to minimize the risk of DILI. Early identification and understanding of potential hepatotoxins are crucial for ensuring drug safety and protecting patients from serious harm.
Prioritizing Liver Health
Maintaining liver health is vital for overall well-being. It's important to avoid excessive alcohol consumption, maintain a healthy weight, and consult with a doctor about any medications you are taking.
Dr.Camel's Conclusion
This research delves into the often-hidden dangers of drug-induced liver injury. Like a camel navigating a desert with unpredictable sandstorms, researchers are seeking ways to predict and prevent this serious side effect. The study highlights the ongoing need for vigilance in drug development and the importance of understanding the potential impact of medications on liver health.
Date :
- Date Completed 2021-11-23
- Date Revised 2021-11-23
Further Info :
Related Literature
English
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