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Long-term effects of adjunctive perampanel on cognition in adolescents with partial seizures.

Author: KumarDinesh, LagaeLieven, LaurenzaAntonio, MeadorKimford J, Piña-GarzaJesus E, RenfroeJ Ben, VillanuevaVicente, WilliamsBetsy

Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Clinical Trial, Phase IIA Phase II trial is a trial that further evaluates the efficacy and safety of a new drug or treatment, whose safety has been confirmed to some extent in a Phase I trial, in a small number of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

Long-term adjunctive treatment with perampanel did not have any significant overall effects on cognition in adolescents with inadequately controlled partial seizures. Perampanel showed sustained long-term seizure control and had a safety and tolerability profile similar to that observed in prior clinical studies.
Paper Details　
Original Abstract of the Article :
OBJECTIVE: The aim of this study was to evaluate long-term effects of adjunctive perampanel on cognition, efficacy, growth, safety, and tolerability in adolescents with inadequately controlled partial seizures. METHODS: Study 235, a multicenter, randomized, double-blind, placebo-controlled, paralle...See full text at original site
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引用元：
https://doi.org/10.1016/j.yebeh.2018.03.029

データ提供：米国国立医学図書館（NLM）

Long-Term Effects of Adjunctive Perampanel on Cognition in Adolescents with Partial Seizures

Navigating the complexities of epilepsy in adolescents is like navigating a treacherous desert. This research explores the long-term effects of perampanel, a medication used to control partial seizures, on the cognitive abilities of teenagers with epilepsy. Using a controlled study design, researchers carefully assessed the effects of perampanel on cognitive function, seizure frequency, and overall safety in adolescents over an extended period. The study revealed that perampanel, while demonstrating sustained seizure control, had no significant negative impact on cognitive performance, providing a glimmer of hope for adolescents with epilepsy.

Sustained Seizure Control with Minimal Cognitive Impact

The study found that perampanel effectively reduced seizure frequency over the long term, providing a much-needed respite from the debilitating effects of epilepsy. This is like finding a reliable source of water in a vast desert, allowing adolescents to thrive and pursue their passions without being hindered by seizures. The study also found no significant negative effects on cognitive function, indicating that perampanel, in this case, did not create a cognitive desert. This is important news for teenagers who need to focus on their studies and overall development.

Navigating the Desert of Epilepsy with Hope

This research offers a beacon of hope for adolescents with epilepsy, demonstrating that long-term treatment with perampanel can effectively control seizures with minimal impact on cognitive function. This is like finding a path through the desert, a safe and effective route to navigate the challenges of epilepsy. It is essential to remember that every individual is different, and what works for one person may not work for another. This study serves as a valuable roadmap for treating adolescents with epilepsy, but it's crucial to consult with a medical professional for personalized guidance and treatment.

Dr. Camel's Conclusion

This study offers a much-needed oasis in the desert of epilepsy for adolescents. Perampanel, like a reliable camel, provides long-term seizure control with minimal impact on cognitive function. This allows teenagers to navigate the challenges of epilepsy with greater confidence and focus on their growth and development.

Date :
  1. Date Completed 2019-02-21
  2. Date Revised 2021-12-04
Further Info :

Pubmed ID

29653338

DOI: Digital Object Identifier

10.1016/j.yebeh.2018.03.029

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Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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