Hematologic Adverse Events Associated With Prolonged Valganciclovir Treatment in Congenital Cytomegalovirus Infection.

Author: AmirJacob, BilavskyEfraim, OsovskyMicky, PardoJoseph, YacobovichJoanne, Yarden-BilavskyHavatzelet, ZivLiron

Paper Details 
Original Abstract of the Article :
Valganciclovir (2/d) therapy for 6 months in neonates with symptomatic congenital cytomegalovirus (cCMV) infection improves hearing and neurodevelopmental outcome. The only reported adverse event was neutropenia. Since 2009, our protocol for symptomatic cCMV infection was a 1-year treatment of 2/d f...See full text at original site
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引用元:
https://doi.org/10.1097/INF.0000000000002079

データ提供:米国国立医学図書館(NLM)

Valganciclovir for Congenital Cytomegalovirus Infection: A Desert of Hope

This study examines the use of valganciclovir, an antiviral medication, for the treatment of symptomatic congenital cytomegalovirus (cCMV) infection, a viral infection that can affect infants during pregnancy or childbirth. The researchers investigated the safety and efficacy of prolonged valganciclovir treatment in neonates with cCMV infection. They reviewed the outcomes of a clinical protocol that involved a one-year course of valganciclovir, with higher doses during the first three months. Their findings suggest that prolonged valganciclovir treatment is well-tolerated and may lead to improved outcomes for infants with cCMV infection.

Navigating the Desert of cCMV Infection

The study found that the most common adverse effect of valganciclovir treatment was neutropenia, a decrease in white blood cell count. However, this effect was generally mild and manageable. The researchers concluded that the potential benefits of valganciclovir treatment outweigh the risks, particularly considering the potential for improved hearing and neurodevelopmental outcomes. It's like navigating a vast desert, where the occasional sandstorm may cause some discomfort but ultimately does not prevent you from reaching your destination.

A Beacon of Hope: Managing cCMV Infection

This study offers hope for infants diagnosed with cCMV infection. It demonstrates that prolonged valganciclovir treatment can be a safe and effective strategy for managing the condition and potentially improving long-term outcomes. It's like a beacon of hope in the desert, guiding families towards a brighter future for their children.

Dr.Camel's Conclusion

This study is like a wellspring of hope in the desert of cCMV infection. It provides valuable insights into the potential benefits of valganciclovir treatment for these infants, offering a glimmer of optimism for families facing this challenge.

Date :
  1. Date Completed 2020-03-06
  2. Date Revised 2020-03-06
Further Info :

Pubmed ID

29677086

DOI: Digital Object Identifier

10.1097/INF.0000000000002079

Related Literature

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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