Successful oral desensitization with osimertinib following osimertinib-induced fever and hepatotoxicity: a case report.

Author: FujimotoDaichi, HirabatakeMasaki, HirabayashiRyosuke, SatsumaYukari, TomiiKeisuke

Paper Details 
Original Abstract of the Article :
Osimertinib is a standard second-line therapy for patients who develop EGFR Thr790Met resistance mutation after treatment with first-line epidermal growth factor receptor tyrosine kinase inhibitors. Although no other effective targeted treatment option exists for these patients, osimertinib might be...See full text at original site
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引用元:
https://doi.org/10.1007/s10637-018-0608-7

データ提供:米国国立医学図書館(NLM)

Osimertinib Desensitization: A Potential Solution for Drug-Induced Toxicity

Osimertinib, a targeted therapy used to treat non-small cell lung carcinoma, can sometimes cause severe drug-induced toxicities like hepatotoxicity. This case report describes the successful oral desensitization with osimertinib in a patient who developed fever and hepatotoxicity after starting treatment. The authors carefully monitored the patient's response to gradually increasing doses of osimertinib, eventually allowing them to resume treatment without experiencing further adverse effects. Their findings suggest that oral desensitization can be a viable option for managing drug-induced toxicities.

Navigating the Desert of Drug Toxicity

The desert of cancer treatment can be treacherous, and drug toxicity can arise like a sandstorm, disrupting progress and causing discomfort. This case report, like a skilled guide leading a caravan through a sandstorm, demonstrates the potential of desensitization to navigate this challenging terrain. It highlights the importance of personalized treatment approaches and the ability to overcome drug-induced toxicity in some cases.

Overcoming Toxicity: A Hopeful Journey

Experiencing drug-induced toxicity during cancer treatment can be disheartening. This case report offers a glimmer of hope, demonstrating the potential of desensitization to overcome this challenge. It emphasizes the importance of open communication with healthcare providers and the need for careful monitoring to ensure safe and effective treatment.

Dr.Camel's Conclusion

The desert of cancer treatment can be a harsh environment, and drug toxicity can be a formidable foe. This case report, like a beacon of hope in the desert, shows that even in the face of toxicity, solutions can be found. Oral desensitization offers a promising strategy for managing drug-induced side effects, reminding us that even in the most challenging circumstances, there are possibilities for resilience and recovery.

Date :
  1. Date Completed 2019-06-03
  2. Date Revised 2022-06-03
Further Info :

Pubmed ID

29721756

DOI: Digital Object Identifier

10.1007/s10637-018-0608-7

Related Literature

SNS
PICO Info
in preparation
Languages

English

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