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Pharmacokinetics of intravenous gentamicin in healthy young-adult compared to aged alpacas.

Author: BedeniceD, CeresiaM, GestrichA, ZaghloulI

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

This study evaluated the effects of age on gentamicin pharmacokinetics in young-adult and aged alpacas. A single 6.6 mg/kg intravenous gentamicin injection achieved target blood concentrations in both age groups, but aged alpacas had significantly lower systemic clearance compared to young alpacas. This suggests a higher risk of gentamicin-related adverse drug reactions in aged alpacas.
Paper Details　
Original Abstract of the Article :
The study objective was to evaluate the effects of age on aminoglycoside pharmacokinetics in eight young-adult (<4 years) and eight aged (≥14 years) healthy alpacas, receiving a single 6.6 mg/kg intravenous gentamicin injection. Heparinized plasma samples were obtained at des...See full text at original site
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引用元：
https://pubmed.ncbi.nlm.nih.gov/29761517

データ提供：米国国立医学図書館（NLM）

Pharmacokinetics of Intravenous Gentamicin in Alpacas

This study investigates the pharmacokinetics of intravenous gentamicin in healthy young-adult and aged alpacas. The researchers administered a single 6.6 mg/kg intravenous gentamicin injection to eight young-adult alpacas (less than 4 years old) and eight aged alpacas (14 years or older). They then collected and analyzed plasma samples at designated time points to determine the drug's pharmacokinetic profile in both age groups. The study found that gentamicin clearance was significantly greater in young-adult alpacas compared to aged animals.

Gentamicin Pharmacokinetics in Alpacas

The study's findings indicate that gentamicin clearance is influenced by age in alpacas. Young-adult alpacas exhibited significantly higher gentamicin clearance compared to aged animals. This information is crucial for optimizing gentamicin dosing in alpacas, ensuring effective treatment while minimizing the risk of adverse drug reactions.

Optimizing Gentamicin Dosing

The research highlights the importance of considering age-related differences in drug pharmacokinetics when treating alpacas with gentamicin. The study's findings provide valuable insights for veterinarians to adjust gentamicin dosing based on age and ensure effective treatment outcomes.

Dr.Camel's Conclusion

Just as the desert landscape is shaped by the passage of time, so too is the body's response to medication influenced by age. This research provides valuable insights into the pharmacokinetics of gentamicin in alpacas, emphasizing the need for age-adjusted dosing strategies to optimize treatment outcomes. The findings underscore the importance of understanding the dynamic nature of drug metabolism and ensuring safe and effective treatment for our animal companions.

Date :
  1. Date Completed 2018-10-16
  2. Date Revised 2020-02-25
Further Info :

Pubmed ID

29761517

DOI: Digital Object Identifier

NIHMS1009721

Related Literature

Article Analysis
・Effects of gentamicin injection
SNS
PICO Info
in preparation
Languages

English

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