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Dissolving polymeric microneedle arrays for enhanced site-specific acyclovir delivery.

Author: DonnellyRyan F, McCarthyHelen O, NgawhirunpatTanasait, PamornpathomkulBoonnada, TekkoIsmaiel A, VoraLalitkumar

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

Acyclovir is a common treatment for cold sores, caused by herpes simplex virus type 1. However, topical acyclovir is poorly absorbed by the skin, limiting its effectiveness. This study evaluated dissolving microneedle arrays for improving acyclovir delivery. These arrays, composed of Gantrez S-97 and containing 361 needles per array, penetrated porcine skin and dissolved within 2 hours. In vitro, acyclovir permeation through skin using the microneedle arrays was 45 times higher compared to a commercial cream formulation. Acyclovir accumulation at the target site, the basal epidermis, was 5 times greater than the concentration needed for viral inhibition. In vivo studies demonstrated successful intradermal delivery of acyclovir over 48 hours, with microneedle array delivery yielding significantly higher drug levels in the skin compared to the cream formulation. Therefore, acyclovir-loaded dissolving microneedle arrays offer a promising approach for effective local acyclovir delivery.
Paper Details　
Original Abstract of the Article :
Acyclovir is widely indicated for the treatment of herpes labialis (cold sores), typically caused by the herpes simplex virus type 1 (HSV-1). However, topical acyclovir has poor efficacy, due to its low skin permeability. The purpose of this study was, therefore, to evaluate the ability of dissolvin...See full text at original site
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引用元：
https://doi.org/10.1016/j.ejps.2018.05.009

データ提供：米国国立医学図書館（NLM）

Delivering Acyclovir: A New Approach to Fight Cold Sores

Herpes labialis, commonly known as cold sores, is a pesky viral infection that can cause painful blisters around the mouth. This study explores a novel approach to delivering acyclovir, a common antiviral drug used to treat cold sores. The researchers, like skilled engineers designing a sophisticated delivery system, investigated the potential of dissolving polymeric microneedle arrays to enhance the local delivery of acyclovir.

Microneedles: A New Path Through the Skin

The study found that dissolving polymeric microneedle arrays significantly improved the delivery of acyclovir to the skin, the primary target of the herpes simplex virus. This is like a caravan using a newly discovered network of paths through the desert, providing a faster and more efficient route to its destination. The microneedles, designed to penetrate the skin's protective barrier, effectively delivered acyclovir to the basal epidermis, the target site of the virus. This is like navigating a treacherous desert landscape, using the needles to create pathways to deliver precious water to the parched earth.

A More Effective Treatment for Cold Sores

The study demonstrated that acyclovir-loaded dissolving microneedle arrays could significantly enhance the delivery of acyclovir, potentially leading to more effective treatment for cold sores. This is like finding a new oasis with a more abundant water source, offering a more effective way to quench the thirst of the desert inhabitants. The results suggest that this new approach could provide a more convenient and potentially more effective treatment option for herpes labialis.

Dr.Camel's Conclusion

This study shows the exciting potential of dissolving polymeric microneedle arrays for effective local delivery of acyclovir. This innovative approach could revolutionize the treatment of herpes labialis, providing a more efficient and effective way to fight this common viral infection. It's a beacon of hope in the desert of cold sore treatments, offering a new path towards a more comfortable and effective solution.

Date :
  1. Date Completed 2019-08-28
  2. Date Revised 2019-08-28
Further Info :

Pubmed ID

29777854

DOI: Digital Object Identifier

10.1016/j.ejps.2018.05.009

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Article Analysis
・Effective treatment of cold sores
SNS
PICO Info
in preparation
Languages

English

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