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Linaclotide Attenuates Visceral Organ Crosstalk: Role of Guanylate Cyclase-C Activation in Reversing Bladder-Colon Cross-Sensitization.

Author: GePei, Greenwood-Van MeerveldBeverley, HannigGerhard, HigginsCarolyn, KurtzCaroline, LigonCasey O, MohammadiEhsan N, Silos-SantiagoAda

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

This study investigated the potential of linaclotide, a guanylate cyclase-C (GC-C) agonist, as a treatment for bladder pain syndrome (BPS). The authors hypothesized that linaclotide could act by inhibiting visceral organ cross-sensitization. Using a rat model, the study demonstrated that linaclotide attenuated both bladder and colonic hyperalgesia induced by protamine sulfate bladder infusion. While having no effect on bladder hyperpermeability, linaclotide significantly inhibited PS-induced colonic hyperpermeability. The study suggests a novel treatment paradigm for GC-C agonism in IBS-C and BPS mediated through a mechanism involving visceral organ crosstalk.
Paper Details　
Original Abstract of the Article :
Bladder pain syndrome (BPS) is poorly understood; however, there is a female predominance and comorbidity with irritable bowel syndrome (IBS). Here we test the hypothesis that linaclotide, a guanylate cyclase-C (GC-C) agonist approved for the treatment of IBS with constipation (IBS-C), may represent...See full text at original site
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引用元：
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6034264/

データ提供：米国国立医学図書館（NLM）

Linaclotide: A New Hope for Bladder Pain Syndrome (BPS)

Bladder pain syndrome (BPS) is a chronic condition characterized by [pelvic pain] and [urinary urgency]. It's like a persistent discomfort in a delicate oasis, interrupting the peaceful flow of life. This research investigates the potential of [linaclotide] as a treatment for BPS, exploring its mechanism of action and its ability to alleviate symptoms. The study examines linaclotide's effects on [visceral organ crosstalk], which is like understanding how different organs in the body communicate and interact, influencing each other's health.

The researchers used a [rat model] to study the effects of linaclotide on bladder and colon sensitivity. They found that linaclotide effectively reduced both bladder and colon hypersensitivity, suggesting a potential therapeutic benefit for patients with BPS. This is like a wise desert nomad using a special herbal remedy to soothe and heal the delicate ecosystem of an oasis.

Linaclotide: A Promising Solution for Bladder Pain

This study suggests that linaclotide may be a promising treatment for BPS, offering relief from painful symptoms. It's like discovering a hidden wellspring in the desert, offering a source of healing and restoration for those suffering from this condition. The findings suggest that linaclotide could be a valuable tool for managing BPS and improving the lives of patients.

Hope for Relief: A New Approach to BPS Treatment

This research provides a glimmer of hope for those suffering from BPS, suggesting a novel approach to treatment. It's like a camel caravan finding a new route through the desert, leading towards a more comfortable and peaceful journey. The findings suggest that linaclotide could offer a new and effective treatment option for this challenging condition.

Dr. Camel's Conclusion

This research explores the potential of linaclotide as a treatment for BPS, highlighting its ability to alleviate symptoms and its mechanism of action through visceral organ crosstalk. It's like a skilled desert nomad utilizing a special blend of herbs to heal and restore harmony to a delicate oasis. The findings suggest that linaclotide could be a valuable tool for managing BPS and improving the lives of patients.

Date :
  1. Date Completed 2019-08-05
  2. Date Revised 2019-08-05
Further Info :

Pubmed ID

29784661

DOI: Digital Object Identifier

PMC6034264

Related Literature

Article Analysis
・Effects of linaclotide
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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