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Vorinostat and quinacrine have synergistic effects in T-cell acute lymphoblastic leukemia through reactive oxygen species increase and mitophagy inhibition.
Author: DengJiong, JinJin, JingBo, LeiHu, LiuMeng, LiuWei, TongYin, WuYingli, XiangRufang, XiaoXinhua, XuHanzhang, YangLi, ZhouLi
Original Abstract of the Article :
Despite recent progress in the treatment, the outcome of adult acute T-cell lymphoblastic leukemia (T-ALL) is poor. Development of novel approach to combat this disease is urgently required. Vorinostat, a pan-histone deacetylase (HDAC) inhibitor, exerts promising anticancer activity in a variety of ...See full text at original site
Dr.Camel's Paper Summary Blogラクダ博士について
ラクダ博士は、Health Journal が論文の内容を分かりやすく解説するために作成した架空のキャラクターです。
難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。
* ラクダ博士による解説は、あくまで論文の要点をまとめたものであり、原論文の完全な代替となるものではありません。詳細な内容については、必ず原論文をご参照ください。
* ラクダ博士は架空のキャラクターであり、実際の医学研究者や医療従事者とは一切関係がありません。
* 解説の内容は Health Journal が独自に解釈・作成したものであり、原論文の著者または出版社の見解を反映するものではありません。
引用元:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5964102/
データ提供:米国国立医学図書館(NLM)
A Synergistic Approach in the Desert of Leukemia: Vorinostat and Quinacrine Join Forces
Imagine a fierce sandstorm sweeping across the desert landscape of the human body, representing T-cell acute lymphoblastic leukemia (T-ALL), a relentless cancer. This study explores the potential of combining two drugs, vorinostat and quinacrine, to combat this aggressive disease. Vorinostat, like a powerful desert wind, targets the tumor cells, while quinacrine, like a clever desert traveler, disrupts the tumor's ability to survive and thrive. The study investigates the synergistic effects of these two drugs, offering a potential new approach to fighting this challenging cancer.
A Desert Alliance: Vorinostat and Quinacrine Fight Together
This study unveils the potential of combining vorinostat and quinacrine to effectively target T-ALL cells. The synergistic effect of these two drugs, working in tandem, offers a promising strategy for combating this aggressive cancer, potentially leading to improved treatment outcomes.
Navigating the Desert of Cancer: Seeking Expert Care
Cancer treatment requires specialized care. It is essential to consult an oncologist or other qualified healthcare professionals for accurate diagnosis, personalized treatment plans, and ongoing support.
Dr.Camel's Conclusion
This study offers a glimpse into a potential oasis in the desert of leukemia, highlighting the synergistic power of combining vorinostat and quinacrine. This new approach, like a clever alliance in the desert, holds the promise of combating T-ALL more effectively, providing hope for patients facing this challenging diagnosis.
Date :
- Date Completed 2019-11-05
- Date Revised 2019-12-10
Further Info :
Related Literature
English
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