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Zurampic Protects Pancreatic β-Cells from High Uric Acid Induced-Damage by Inhibiting URAT1 and Inactivating the ROS/AMPK/ERK Pathways.

Author: ChenRui, DuZhongcai, JiaZhaotong, LiuJia, SunJianjing, WangKun, XinYing, XuQiang, XuTao, ZhangChao

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Retracted PublicationCases where a publication has been formally withdrawn due to the discovery of serious errors or misconduct.

Overview

Zurampic has a protective effect on pancreatic β-cells against uric acid induced-damage by inhibiting URAT1 and inactivating the ROS/AMPK/ERK pathway.
Paper Details　
Original Abstract of the Article :
BACKGROUND/AIMS: Zurampic is a US FDA approved drug for treatment of gout. However, the influence of Zurampic on pancreatic β-cells remains unclear. The study aimed to evaluate the effects of Zurampic on high uric acid-induced damage of pancreatic β-cells and the possible underlying mechanisms. MET...See full text at original site
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引用元：
https://doi.org/10.1159/000490184

データ提供：米国国立医学図書館（NLM）

Zurampic: A Protective Oasis for Pancreatic β-Cells

High uric acid levels can disrupt the delicate balance of the body, like a sandstorm threatening a fragile oasis. This study investigates the protective effects of Zurampic, a drug used to treat gout, on pancreatic β-cells, which are responsible for producing insulin. The researchers investigated the potential of Zurampic to mitigate the damaging effects of high uric acid on these vital cells.

Zurampic: A Shield Against Uric Acid

The study found that Zurampic effectively protected pancreatic β-cells from uric acid-induced damage by inhibiting a specific transporter (URAT1) and inactivating signaling pathways involved in cellular stress. This suggests that Zurampic may have a broader role in protecting cellular health, particularly in conditions involving high uric acid levels.

A Healthier Landscape for Pancreatic β-Cells

This study highlights the potential protective effects of Zurampic on pancreatic β-cells, offering a potential avenue for mitigating the negative effects of high uric acid. It's like finding a protective oasis in the desert of high uric acid, shielding vital cells from harm.

Dr. Camel's Conclusion

This study explores the protective effects of Zurampic on pancreatic β-cells in the context of high uric acid levels. The findings suggest that Zurampic could play a valuable role in maintaining cellular health, particularly in conditions involving high uric acid. It's a reminder that the desert of metabolic research is vast and full of opportunities for understanding and protecting cellular function.

Date :
  1. Date Completed 2018-08-15
  2. Date Revised 2021-11-04
Further Info :

Pubmed ID

29843128

DOI: Digital Object Identifier

10.1159/000490184

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Languages

English

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