[Machine Learning-based Prediction of Seizure-inducing Action as an Adverse Drug Effect].

Author: GaoMengxuan, IkegayaYuji, SatoMotoshige

Paper Details 
Original Abstract of the Article :
During the preclinical research period of drug development, animal testing is widely used to help screen out a drug's dangerous side effects. However, it remains difficult to predict side effects within the central nervous system. Here, we introduce a machine learning-based in vitro system designed ...See full text at original site
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引用元:
https://doi.org/10.1248/yakushi.17-00213-1

データ提供:米国国立医学図書館(NLM)

Predicting Seizure-Inducing Adverse Drug Effects with Machine Learning

Predicting potential side effects of drugs during the development process is crucial to ensure patient safety. This study, like a group of explorers venturing into uncharted territory, uses machine learning to develop an in vitro system for detecting seizure-inducing side effects before clinical trials. The researchers recorded neuronal activity in mouse brain slices exposed to various drugs, analyzing the data using machine learning algorithms to identify those drugs with seizure-inducing potential.

Artificial intelligence: a new tool for drug safety

The study demonstrated the potential of machine learning in identifying drugs with seizure-inducing properties. The researchers successfully identified four drugs known to cause seizures in clinical settings, highlighting the system's ability to predict adverse events. This advancement is like discovering a new oasis in the desert of drug safety, offering a more efficient and accurate way to identify potential risks before they reach patients.

Navigating the desert of drug development

This study emphasizes the evolving role of artificial intelligence in drug development. By using machine learning algorithms to analyze in vitro data, researchers can potentially improve the safety and efficacy of new medications. Just as a camel navigating the desert relies on its instincts to avoid dangerous terrain, this technology can help researchers avoid potential hazards in the drug development process.

Dr. Camel's Conclusion

This research showcases the exciting potential of artificial intelligence in improving drug safety. By using machine learning to identify seizure-inducing side effects, researchers can potentially prevent patients from experiencing these harmful effects. This is a promising step forward in ensuring the safe and effective development of new medications.

Date :
  1. Date Completed 2018-08-03
  2. Date Revised 2018-08-03
Further Info :

Pubmed ID

29863052

DOI: Digital Object Identifier

10.1248/yakushi.17-00213-1

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PICO Info
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Languages

Japanese

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