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Mu-opioid antagonists for opioid-induced bowel dysfunction in people with cancer and people receiving palliative care.

Author: CandyBridget, JonesLouise, LarkinPhilip J, StonePatrick, VickerstaffVictoria

Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Overview

Mu-opioid antagonists (MOAs), including methylnaltrexone, are used for the management of opioid-induced bowel dysfunction (OIBD) in people with cancer and people receiving palliative care.
Paper Details　
Original Abstract of the Article :
Opioid-induced bowel dysfunction (OIBD) is characterised by constipation, incomplete evacuation, bloating, and gastric reflux. It is one of the major adverse events of treatment for pain in cancer and in palliative care, resulting in increased morbidity and reduced quality of life.This is an update ...See full text at original site
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引用元：
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6513061/

データ提供：米国国立医学図書館（NLM）

Addressing Opioid-Induced Bowel Dysfunction (OIBD)

Treating pain effectively is a crucial aspect of healthcare, but opioid medications can sometimes cause unpleasant gastrointestinal side effects. This review examines the use of mu-opioid antagonists (MOAs) for managing opioid-induced bowel dysfunction (OIBD) in people with cancer and those receiving palliative care. The authors conducted an updated review of randomized controlled trials evaluating the efficacy of MOAs for OIBD.

MOAs Show Potential for Managing OIBD

The review found that MOAs can be effective in managing OIBD, improving symptoms such as constipation, bloating, and gastric reflux. The authors noted that MOAs offer a promising option for reducing the discomfort associated with OIBD, allowing patients to manage their pain more effectively. This study suggests that MOAs can be a valuable tool for managing OIBD, allowing individuals to navigate the desert of gastrointestinal discomfort and reach the oasis of improved quality of life.

The Importance of Managing OIBD

This review highlights the importance of addressing OIBD, a common side effect of opioid therapy. The research suggests that MOAs can be effective in managing this condition, improving patient comfort and overall well-being. The study reminds us that navigating the desert of pain management requires a comprehensive approach, addressing both pain relief and potential gastrointestinal side effects.

Dr. Camel's Conclusion

This review emphasizes the importance of managing OIBD, a common side effect of opioid therapy. The findings suggest that MOAs can be an effective tool for alleviating the discomfort associated with OIBD, improving patient quality of life and enabling them to manage their pain effectively. This research is a reminder that navigating the desert of pain management requires a comprehensive approach, addressing both pain relief and potential side effects.
Date :
  1. Date Completed 2018-08-14
  2. Date Revised 2022-09-19
Further Info :

Pubmed ID

29869799

DOI: Digital Object Identifier

PMC6513061

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Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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