Paper Details

  1. Home
  2. Paper Details

Sub-efficacious doses of phosphodiesterase 4 and 5 inhibitors improve memory in a mouse model of Alzheimer's disease.

Author: ArancioOttavio, GulisanoWalter, PalmeriAgostino, PuzzoDaniela, TropeaMaria Rosaria

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

Chronic treatment with a combination of sub-efficacious doses of roflumilast and vardenafil improved recognition, spatial, and contextual fear memory in APPswe mice.
Paper Details　
Original Abstract of the Article :
Cyclic nucleotides cAMP and cGMP cooperate to ensure memory acquisition and consolidation. Increasing their levels by phosphodiesterase inhibitors (PDE-Is) enhanced cognitive functions and rescued memory loss in different models of aging and Alzheimer's disease (AD). However, side effects due to the...See full text at original site
Dr.Camel IconDr.Camel's Paper Summary Blogラクダ博士について

ラクダ博士は、Health Journal が論文の内容を分かりやすく解説するために作成した架空のキャラクターです。
難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。

* ラクダ博士による解説は、あくまで論文の要点をまとめたものであり、原論文の完全な代替となるものではありません。詳細な内容については、必ず原論文をご参照ください。
* ラクダ博士は架空のキャラクターであり、実際の医学研究者や医療従事者とは一切関係がありません。
* 解説の内容は Health Journal が独自に解釈・作成したものであり、原論文の著者または出版社の見解を反映するものではありません。


引用元：
https://doi.org/10.1016/j.neuropharm.2018.06.002

データ提供：米国国立医学図書館（NLM）

Combating Alzheimer's Disease: Finding a Hidden Oasis in the Desert of Memory Loss

Alzheimer's disease, a devastating neurodegenerative condition, robs individuals of their memories and cognitive abilities. This study investigates the potential of phosphodiesterase inhibitors (PDE-Is) in treating Alzheimer's disease. The authors explore the use of sub-efficacious doses of PDE-Is, aiming to enhance cognitive function and minimize side effects. Their findings provide promising insights into the potential of combination therapy in combating Alzheimer's disease.

A Combination Therapy Oasis in the Desert of Alzheimer's

This research offers a glimmer of hope in the vast desert of Alzheimer's disease. The authors' findings suggest that a combination of sub-efficacious doses of PDE-Is can improve memory in a mouse model of Alzheimer's disease. This approach provides a potential avenue for developing effective therapies that minimize side effects, a significant advantage for patients.

Finding a Balance in the Desert of Treatment

Navigating the desert of Alzheimer's treatment requires a delicate balance of efficacy and safety. This study highlights the potential of combination therapy, specifically utilizing sub-efficacious doses, to achieve better outcomes while minimizing side effects. While further research is necessary, this study provides a promising direction for developing new therapies for Alzheimer's disease.

Dr.Camel's Conclusion

This research illuminates a potential oasis in the vast and unforgiving desert of Alzheimer's disease. The study's findings offer a glimmer of hope for individuals affected by this devastating condition, suggesting that a combination of sub-efficacious doses of PDE-Is can improve memory function and reduce side effects. While much work remains to be done, this research offers a valuable stepping stone towards developing effective treatments for Alzheimer's disease.

Date :
  1. Date Completed 2019-02-13
  2. Date Revised 2019-02-15
Further Info :

Pubmed ID

29885420

DOI: Digital Object Identifier

10.1016/j.neuropharm.2018.06.002

Related Literature

Article Analysis
・Side Effects of roflumilast
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

This site uses cookies. Visit our privacy policy page or click the link in any footer for more information and to change your preferences.