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Using fMRI to evaluate the effects of milnacipran on central pain processing in patients with fibromyalgia.

Author: CarvilleS, ChoyE, FranssonP, GracelyR H, IngvarM, JensenK B, KosekE, MainguyY, MarcusH, PetzkeF, WilliamsS C R

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

Milnacipran, an SNRI approved for fibromyalgia (FM), was investigated for its effects on pressure-evoked pain sensitivity and cerebral processing using fMRI. The study found a trend toward lower pain sensitivity and increased pain-evoked brain activity in pain inhibitory regions after treatment. Further research is needed to confirm these findings and explore the role of the default mode network in FM.
Paper Details　
Original Abstract of the Article :
Background In recent years, the prescription of serotonin-noradrenalin reuptake inhibitors (SNRIs) for treatment of fibromyalgia (FM) has increased with reports of their efficacy. The SNRI milnacipran is approved by the U.S. Food and Drug Administration (FDA) for treatment of FM, yet, the mechanisms...See full text at original site
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引用元：
https://doi.org//j/sjpain.2013.4.issue-2/j.sjpain.2012.10.002/j.sjpain.2012.10.002.xml

データ提供：米国国立医学図書館（NLM）

Milnacipran and Central Pain Processing in Fibromyalgia: A Neuroimaging Study

This research investigates the effects of milnacipran, a serotonin-noradrenalin reuptake inhibitor (SNRI), on central pain processing in patients with fibromyalgia (FM), a chronic pain disorder. The researchers used functional magnetic resonance imaging (fMRI) to assess changes in brain activity in response to pressure-evoked pain before and after treatment with milnacipran or placebo. They found that milnacipran-treated patients showed a trend towards lower pressure-pain sensitivity and increased activity in brain regions implicated in pain inhibitory processes.

Milnacipran and Pain Inhibition: A Glimpse into the Brain

The study provides evidence that milnacipran may influence central pain processing in FM patients. The researchers' findings suggest that this medication could potentially modulate pain perception by increasing activity in brain regions involved in pain inhibition. It's like discovering a hidden oasis in the desert of pain, offering a potential pathway to relief.

Understanding Pain Processing: A Journey Towards Better Pain Management

This research highlights the importance of understanding the complex interplay between brain activity and pain perception in chronic pain conditions like fibromyalgia. The findings suggest that targeting specific brain regions involved in pain processing could potentially lead to more effective pain management strategies.

Dr.Camel's Conclusion

This research provides valuable insights into the effects of milnacipran on central pain processing in patients with fibromyalgia. The findings suggest that milnacipran could potentially modulate pain perception by increasing activity in brain regions involved in pain inhibition. This research emphasizes the importance of understanding the complex interplay between brain activity and pain perception in chronic pain conditions, potentially leading to more effective pain management strategies.

Date :
  1. Date Completed n.d.
  2. Date Revised 2019-11-20
Further Info :

Pubmed ID

29913906

DOI: Digital Object Identifier

/j/sjpain.2013.4.issue-2/j.sjpain.2012.10.002/j.sjpain.2012.10.002.xml

SNS
PICO Info
in preparation
Languages

English

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