Sonidegib, a Novel Inhibitor of Suicidal Erythrocyte Death.

Author: Al Mamun BhuyanAbdulla, CaoHang, LangFlorian, SahuItishri

Paper Details 
Original Abstract of the Article :
The Hedgehog pathway disrupting drug sonidegib is used in the treatment of basal cell carcinoma. Side effects of sonidegib include anemia, which could result either from impaired erythropoiesis or from loss of erythrocytes e.g. due to suicidal erythrocyte death or eryptosis, which is characterized b...See full text at original site
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引用元:
https://doi.org/10.1159/000490820

データ提供:米国国立医学図書館(NLM)

Sonidegib: A Desert Oasis for Suicidal Erythrocytes

The red blood cells, the tireless workhorses of our circulatory system, carry oxygen throughout the body. Imagine a camel traversing a vast desert, relying on its stamina to reach its destination. Similarly, red blood cells are essential for life, delivering vital oxygen to every cell in the body. However, these cells can also be vulnerable to stress and damage, potentially leading to their premature death. This study explores the impact of sonidegib, a drug used to treat basal cell carcinoma, on suicidal erythrocyte death, also known as eryptosis, revealing a potential link between this medication and red blood cell health.

Sonidegib: A Potential Threat to Red Blood Cell Survival

The study investigates the potential of sonidegib to induce eryptosis, highlighting the potential for this medication to affect red blood cell survival. Imagine a desert oasis, where a sudden drought dries up the water source, leaving travelers vulnerable and thirsty. Similarly, sonidegib may disrupt the delicate balance within red blood cells, potentially triggering their premature demise. This research underscores the importance of considering the potential effects of medications on red blood cell health, especially in patients already at risk for anemia.

The Importance of Monitoring Red Blood Cell Health

This study emphasizes the importance of monitoring red blood cell health in patients taking sonidegib. Imagine a camel navigating a desert landscape, carefully monitoring its water supply to ensure its survival. Similarly, healthcare providers must pay close attention to red blood cell counts and other markers of red blood cell health in patients taking sonidegib, ensuring prompt intervention if necessary. This research highlights the importance of careful monitoring and preventative measures in preserving red blood cell health and minimizing the risk of adverse effects.

Dr. Camel's Conclusion

Sonidegib, a medication used to treat basal cell carcinoma, may have unintended consequences for red blood cell health, potentially triggering their premature demise. Just as a desert oasis can dry up and leave travelers vulnerable, sonidegib can disrupt the delicate balance within red blood cells. This research underscores the importance of careful monitoring and preventative measures to protect red blood cell health, ensuring the safety and well-being of patients taking this medication.

Date :
  1. Date Completed 2018-08-15
  2. Date Revised 2019-12-10
Further Info :

Pubmed ID

29929201

DOI: Digital Object Identifier

10.1159/000490820

Related Literature

SNS
PICO Info
in preparation
Languages

English

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