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HSD3B1(1245A>C) variant regulates dueling abiraterone metabolite effects in prostate cancer.

Author: AlmassiNima, AlyamaniMohammad, AuchusRichard J, BerkMichael P, ChienCaly, EmamekhooHamid, FiggWilliam Douglas, GarciaJorge, GrivasPetros, HuBo, HwangTae Hyun, KoshkinVadim S, MendirattaPrateek, ParkSunho, PeerCody J, RiniBrian, SharifiNima, TaylorJennifer, TylerAllison, UpadhyaySunil

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Overview

Patients with a common germline variant in HSD3B1(1245A>C) may experience increased 3-keto-5α-abiraterone synthesis, which could impact the efficacy of abiraterone treatment for prostate cancer.
Paper Details　
Original Abstract of the Article :
A common germline variant in HSD3B1(1245A>C) encodes for a hyperactive 3β-hydroxysteroid dehydrogenase 1 (3βHSD1) missense that increases metabolic flux from extragonadal precursor steroids to DHT synthesis in prostate cancer. Enabling of extragonadal DHT synthesis by HSD3B1(1245C) predicts for more...See full text at original site
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引用元：
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6063492/

データ提供：米国国立医学図書館（NLM）

HSD3B1(1245A>C) Variant: A Key Player in Prostate Cancer Treatment

This research examines the role of a common genetic variant in HSD3B1, a gene involved in hormone metabolism, in prostate cancer. Imagine a camel caravan traveling through the desert. This study explores how a specific genetic variation can impact the caravan's journey. The researchers discovered that this genetic variant affects how the body metabolizes androgens, male hormones that play a role in prostate cancer. The study suggests that men with this specific variant may be more susceptible to prostate cancer and respond differently to certain treatments. Specifically, the variant can affect the effectiveness of abiraterone, a medication used to block the production of androgens. This research provides valuable insights into the complex relationship between genetics and prostate cancer, paving the way for more personalized treatment approaches. This study is like a desert guidebook, helping us navigate the complexities of prostate cancer and tailor treatment strategies to each patient's unique genetic makeup.

HSD3B1(1245A>C) Variant: Personalized Treatment for Prostate Cancer

This research highlights the potential of genetic testing to personalize prostate cancer treatment. The findings suggest that men with the HSD3B1(1245A>C) variant may benefit from specific treatment strategies, improving their chances of successful treatment.

Prostate Cancer: A Journey Through Genetics and Treatment

Prostate cancer is a complex condition. This research provides valuable insights into the role of genetics in influencing treatment outcomes, reminding us that personalized medicine is essential for achieving the best possible results.

Dr.Camel's Conclusion

This study, like a desert expedition, delves into the complex world of genetics and its impact on prostate cancer. By understanding the role of specific genetic variants, researchers are paving the way for more personalized treatment approaches. This research is a testament to the power of scientific discovery and its potential to improve our understanding of complex diseases and develop more effective treatment strategies.

Date :
  1. Date Completed 2019-09-10
  2. Date Revised 2023-08-21
Further Info :

Pubmed ID

29939161

DOI: Digital Object Identifier

PMC6063492

Related Literature

Article Analysis
・Effects of abiraterone
SNS
PICO Info
in preparation
Languages

English

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