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Cabozantinib-induced serum creatine kinase elevation and musculoskeletal complaints.

Author: CronaDaniel J, StumpSarah E, WhangYoung E

Case ReportsIn the medical field, a report that describes in detail a unique case, an unusual medical condition, or the effect of a treatment. Provides new insights and possibilities for treatment through individual patient cases.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

This case report describes a patient with renal cell carcinoma who developed creatine kinase (CK) elevation after starting cabozantinib treatment. CK elevation was associated with musculoskeletal complaints. Cabozantinib was discontinued, and CK levels returned to baseline. This suggests a potential for under-reported cabozantinib-induced CK elevations, and providers should monitor for musculoskeletal complaints during cabozantinib therapy.
Paper Details　
Original Abstract of the Article :
Cabozantinib is a multikinase inhibitor approved for the treatment of metastatic medullary thyroid cancer and advanced renal cell carcinoma (RCC) in patients who have received prior anti-angiogenic therapy. While associations between serum creatine kinase (CK) elevations and other tyrosine kinase in...See full text at original site
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引用元：
https://doi.org/10.1007/s10637-018-0629-2

データ提供：米国国立医学図書館（NLM）

Cabozantinib and Musculoskeletal Side Effects

The use of [Cabozantinib], a [Multikinase inhibitor], in the treatment of [Metastatic medullary thyroid cancer and advanced renal cell carcinoma] is an important topic in [Oncology]. This research reports a case of [Cabozantinib-induced serum creatine kinase elevation] associated with [Musculoskeletal complaints]. The authors highlight the [Temporal relationship between drug exposure and CK increase] and emphasize the need for [Monitoring for musculoskeletal complaints] during cabozantinib therapy.

Understanding Cabozantinib's Side Effects

The case report suggests that [Cabozantinib] can cause [Serum creatine kinase elevation] and [Musculoskeletal complaints]. Healthcare professionals should be aware of these potential side effects to [Optimize patient care and manage potential complications].

Navigating Cancer Treatment

Patients undergoing [Cancer treatment] should [Communicate openly with their healthcare providers] about any [Side effects] they experience. This open dialogue is crucial for [Ensuring appropriate management and minimizing potential complications].

Dr.Camel's Conclusion

This research, like a desert traveler encountering a hidden danger, reveals a potential side effect of cabozantinib treatment. While cabozantinib offers valuable therapeutic benefits, understanding its potential risks, like navigating a treacherous desert path, is essential for ensuring patient safety. Continued vigilance and open communication are crucial in navigating this complex landscape of cancer treatment.

Date :
  1. Date Completed 2019-06-10
  2. Date Revised 2019-06-13
Further Info :

Pubmed ID

29956055

DOI: Digital Object Identifier

10.1007/s10637-018-0629-2

Related Literature

Article Analysis
・Effects of cabozantinib (thyroid cancer)
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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