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Lacosamide may improve cognition in patients with focal epilepsy: EpiTrack to compare cognitive side effects of lacosamide and carbamazepine.

Author: IzziFrancesca, LiguoriClaudio, ManfrediNatalia, MercuriNicola Biagio, PlacidiFabio

Case ReportsIn the medical field, a report that describes in detail a unique case, an unusual medical condition, or the effect of a treatment. Provides new insights and possibilities for treatment through individual patient cases.

Overview

Lacosamide (LCM) and carbamazepine (CBZ) were found to be equally effective in treating uncontrolled focal seizures in patients with epilepsy. LCM showed improved cognitive abilities compared to CBZ.
Paper Details　
Original Abstract of the Article :
Carbamazepine (CBZ) is a first generation anti-seizure drug, considered as first choice therapy in focal epilepsy but associated with cognitive side effects. Lacosamide (LCM) is a third-generation anti-seizure drug approved for treating focal epilepsy. This case series documented the comparable effi...See full text at original site
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引用元：
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6030027/

データ提供：米国国立医学図書館（NLM）

Lacosamide may improve cognition in patients with focal epilepsy: EpiTrack to compare cognitive side effects of lacosamide and carbamazepine

This research explores the potential cognitive effects of lacosamide, a third-generation anti-seizure drug, compared to carbamazepine (CBZ), a first-generation anti-seizure drug. The study utilizes a case series approach to compare the efficacy and cognitive impact of lacosamide and CBZ as add-on treatments for patients with uncontrolled focal seizures.

Lacosamide Shows Potential Cognitive Benefits

The preliminary data suggests that lacosamide may have a more favorable cognitive profile than CBZ. The patients treated with lacosamide demonstrated an increase in EpiTrack scores, which measure cognitive abilities, at follow-up compared to those treated with CBZ. These findings warrant further investigation to confirm the potential cognitive benefits of lacosamide and explore its long-term cognitive impact.

Implications for Epilepsy Management

This research highlights the importance of considering the cognitive effects of anti-seizure medications, particularly in the context of long-term treatment. The findings suggest that lacosamide, with its potential cognitive benefits, may offer a valuable alternative for patients with focal epilepsy who are concerned about cognitive side effects. The desert of epilepsy management is vast and complex, and finding the right oasis – a treatment that effectively controls seizures without compromising cognitive function – is a constant pursuit.

Dr.Camel's Conclusion

This case series provides promising preliminary data suggesting that lacosamide may have a more favorable cognitive profile than carbamazepine for patients with focal epilepsy. These findings warrant further investigation with larger, prospective studies to confirm the potential cognitive benefits of lacosamide. As we navigate the challenging terrain of epilepsy management, research like this offers hope for new and improved treatment options that can improve the lives of patients and allow them to thrive.

Date :
  1. Date Completed n.d.
  2. Date Revised 2020-10-01
Further Info :

Pubmed ID

29977793

DOI: Digital Object Identifier

PMC6030027

Related Literature

Article Analysis
・Side Effects of carbamazepine
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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