Uridine triacetate for severe 5-fluorouracil toxicity in a patient with thymidylate synthase gene variation: Potential pharmacogenomic implications.

Author: BaldeoCandice, KasiPashtoon Murtaza, ModyKabir, VishnuPrakash

Paper Details 
Original Abstract of the Article :
Adverse drug reactions can be unpredictable. However, pharmacogenomic testing can help identify patients who may be more susceptible to the toxic effects of certain drugs. Genetic variations in the dihydropyrimidine dehydrogenase and thymidylate synthase genes have been shown to increase the risk of...See full text at original site
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引用元:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6041857/

データ提供:米国国立医学図書館(NLM)

Uridine Triacetate: A New Oasis in the Desert of 5-Fluorouracil Toxicity

The world of chemotherapy is a challenging landscape, much like navigating a vast desert with its own unique dangers. 5-Fluorouracil, a common chemotherapy drug, can cause serious side effects, including life-threatening toxicity. This case report takes us on a journey through a complex medical scenario, where a patient experienced severe 5-fluorouracil toxicity and was successfully treated with uridine triacetate. The authors highlight the importance of pharmacogenomic testing in identifying patients who may be more susceptible to drug toxicity and explore the potential for uridine triacetate to serve as a life-saving intervention.

Navigating the Desert of Chemotherapy Toxicity: Finding a Path to Recovery

This case report demonstrates the potential of uridine triacetate to effectively treat severe 5-fluorouracil toxicity. The authors highlight the importance of pharmacogenomic testing in identifying patients at risk for drug toxicity and provide a compelling example of how uridine triacetate can be a life-saving intervention. This case study underscores the importance of personalized medicine and the need for vigilant monitoring and prompt intervention to minimize chemotherapy-related complications.

The Desert of Chemotherapy: A Complex Landscape

This case report serves as a reminder of the complex challenges faced by patients undergoing chemotherapy. The authors' experience highlights the potential for severe toxicity, even with seemingly routine medications. This case study emphasizes the importance of individualized care and the need for ongoing research to develop new and safer chemotherapy agents.

Dr. Camel's Conclusion

This case report underscores the importance of personalized medicine and the potential of pharmacogenomics to guide patient care. The authors' experience highlights the value of uridine triacetate as a life-saving intervention for severe 5-fluorouracil toxicity. This research serves as a reminder that even in the seemingly harsh desert of chemotherapy, hope and healing can be found with the right tools and a compassionate approach.

Date :
  1. Date Completed n.d.
  2. Date Revised 2020-10-01
Further Info :

Pubmed ID

30013790

DOI: Digital Object Identifier

PMC6041857

Related Literature

SNS
PICO Info
in preparation
Languages

English

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