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Impact of natural polymorphisms of HIV-1 non-group M on genotypic susceptibility to the attachment inhibitor fostemsavir.

Author: Alessandri-GradtElodie, CharpentierCharlotte, DescampsDiane, LeozMarie, MourezThomas, PlantierJean-Christophe

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

Fostemsavir, a promising attachment inhibitor (AI) for HIV treatment, has been shown to be effective against most HIV-1 groups. However, previous studies indicated potential resistance in divergent HIV-1 group O. This study aims to investigate the susceptibility of other divergent groups, N and P, to fostemsavir.
Paper Details　
Original Abstract of the Article :
Fostemsavir belongs to the new class of attachment inhibitors (AIs); it inhibits the entry of HIV into CD4+ T-lymphocytes by blocking conformational changes in gp120. This is a promising AI, but previous phenotypic data showed that genetically divergent HIV-1 group O could present natural resistance...See full text at original site
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引用元：
https://doi.org/10.1093/jac/dky271

データ提供：米国国立医学図書館（NLM）

Natural Polymorphisms and Fostemsavir Susceptibility: A Look at Divergent HIV-1 Groups

This research delves into the fascinating world of HIV-1, exploring the impact of natural genetic variations on the susceptibility of different HIV-1 groups to a new class of drugs called attachment inhibitors (AIs). The study focuses on fostemsavir, an AI that blocks HIV entry into CD4+ T-lymphocytes by interfering with conformational changes in the gp120 protein. The researchers investigated the susceptibility of genetically divergent HIV-1 groups, including groups O, N, and P, to fostemsavir. The study found that HIV-1 group O exhibited natural resistance to fostemsavir, highlighting the importance of considering genetic diversity when evaluating drug efficacy. This research underscores the need for further investigation into the susceptibility of different HIV-1 groups to fostemsavir and other AIs to ensure effective treatment strategies.

Genetic Diversity and HIV Drug Resistance: A Complex Landscape

The study highlights the complex relationship between genetic diversity in HIV-1 and drug resistance. This finding underscores the importance of comprehensive genetic testing and individualized treatment strategies to ensure optimal drug efficacy and prevent the emergence of resistance.

Understanding HIV Treatment Strategies: A Patient's Guide

Individuals living with HIV should discuss treatment options with their healthcare providers, including the potential for drug resistance. Comprehensive genetic testing can help guide personalized treatment strategies and optimize drug efficacy. Remember, a proactive approach to HIV management is essential for long-term health and well-being.

Dr.Camel's Conclusion

This research, like a seasoned traveler navigating the diverse and complex landscape of HIV-1, highlights the importance of understanding genetic variations and their impact on drug susceptibility. This knowledge, like a compass guiding our journey through the desert of HIV treatment, is crucial for developing effective and personalized strategies to combat this challenging disease.
Date :
  1. Date Completed 2019-10-03
  2. Date Revised 2019-10-07
Further Info :

Pubmed ID

30032194

DOI: Digital Object Identifier

10.1093/jac/dky271

Related Literature

Article Analysis
・Effects of fostemsavir
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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