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A case report of toxic epidermal necrolysis associated with AZD-9291.

Author: ChengXianYe, LuYan, WangJie, ZhouBingRong

Case ReportsIn the medical field, a report that describes in detail a unique case, an unusual medical condition, or the effect of a treatment. Provides new insights and possibilities for treatment through individual patient cases.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

A case of toxic epidermal necrolysis, a severe skin reaction, is reported in a patient after taking AZD-9291, an EGFR-TKI.
Paper Details　
Original Abstract of the Article :
Epidermal growth factor receptor-tyrosine kinase inhibitors (EGFR-TKIs) are a strain of small molecule inhibitors mainly used to treat the metastatic non-small cell lung cancer. Their predominant adverse effect is skin toxicity, usually manifested as acneiform rash, skin fissure, xerosis, and parony...See full text at original site
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難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。

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引用元：
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6047856/

データ提供：米国国立医学図書館（NLM）

Toxic Epidermal Necrolysis: A Rare and Severe Side Effect of AZD-9291

Epidermal growth factor receptor-tyrosine kinase inhibitors (EGFR-TKIs), like a powerful desert wind, target specific pathways involved in cancer growth. While these drugs are generally effective, they can sometimes cause severe side effects. This case report highlights a rare and serious side effect of AZD-9291, a new generation EGFR-TKI, known as toxic epidermal necrolysis (TEN), a life-threatening skin reaction.

A Warning Sign: Toxic Epidermal Necrolysis

The patient developed widespread skin necrosis and was diagnosed with TEN after taking AZD-9291. This case serves as a reminder that even with advanced therapies, potential adverse effects must be carefully monitored. It's like navigating a treacherous desert landscape, where unexpected dangers can lurk even amidst the most promising oases.

Understanding the Risks and Benefits

This case report emphasizes the importance of understanding the potential risks and benefits of any medication. It highlights the need for vigilant monitoring and prompt intervention in case of severe reactions. Imagine a wise desert guide, equipped with knowledge and experience, ensuring the safety of those venturing into the unknown.

Dr. Camel's Conclusion

This case report serves as a valuable reminder that even with the advent of new and innovative therapies, vigilant monitoring for adverse effects is essential. By understanding the risks and benefits of each treatment, we can best navigate the complex landscape of medicine and provide optimal care for our patients.
Date :
  1. Date Completed 2018-12-11
  2. Date Revised 2022-06-03
Further Info :

Pubmed ID

30034220

DOI: Digital Object Identifier

PMC6047856

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