Efficacy and safety of sodium oxybate in alcohol-dependent patients with a very high drinking risk level.

Author: AddoloratoGiovanni, AubinHenri-Jean, BenyaminaAmine, CaputoFabio, DematteisMaurice, GualAntoni, LeschOtto-Michael, MannKarl, MaremmaniIcro, NuttDavid, PailleFrançois, PerneyPascal, RehmJürgen, ReynaudMichel, SimonNicolas, SommerWolfgang H, SpanagelRainer, SöderpalmBo, WalterHenriette, van den BrinkWim

Paper Details 
Original Abstract of the Article :
Medication development for alcohol relapse prevention or reduction of consumption is highly challenging due to methodological issues of pharmacotherapy trials. Existing approved medications are only modestly effective with many patients failing to benefit from these therapies. Therefore, there is a ...See full text at original site
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引用元:
https://doi.org/10.1111/adb.12645

データ提供:米国国立医学図書館(NLM)

Sodium Oxybate for Alcohol Dependence

This study dives into the complex world of alcohol dependence and explores the potential of sodium oxybate as a treatment for patients with a very high drinking risk level. The researchers point to the challenges associated with developing effective medications for alcohol relapse prevention, as many existing therapies only offer modest benefits. They emphasize the urgent need for new treatment options with a different mechanism of action, especially for patients with a very high drinking risk level, who are at greatest risk for severe consequences related to alcohol abuse. The study provides compelling evidence that sodium oxybate may be effective in reducing alcohol consumption and promoting abstinence, particularly in this high-risk population.

Sodium Oxybate Shows Promise for Alcohol Dependence

The study's findings indicate that sodium oxybate, a compound that acts on GABA receptors in the brain, may be a promising treatment option for alcohol-dependent individuals with a very high drinking risk level. The study's results, which include data from published trials, unpublished large clinical trials, post hoc subgroup analyses, and multiple meta-analyses, suggest that sodium oxybate can significantly increase abstinence rates and reduce alcohol consumption in this high-risk population. The findings are particularly encouraging given the limited effectiveness of existing medications for alcohol dependence.

Alcohol Dependence and Treatment Options

If you or someone you know is struggling with alcohol dependence, it's crucial to seek professional help. A qualified healthcare provider can assess your individual needs and guide you toward the most effective treatment options. Remember, my dear friends, overcoming addiction is a journey that requires courage, support, and access to appropriate resources. It's important to seek help and to believe in your ability to recover.

Dr.Camel's Conclusion

This study provides compelling evidence that sodium oxybate may be a valuable treatment option for alcohol dependence, particularly in patients with a very high drinking risk level. The research highlights the importance of exploring new therapeutic approaches to address this significant public health concern. Remember, my dear friends, the desert of addiction can be vast and daunting, but with the right support and guidance, we can find our way to healing and recovery.

Date :
  1. Date Completed 2019-10-07
  2. Date Revised 2019-10-07
Further Info :

Pubmed ID

30043457

DOI: Digital Object Identifier

10.1111/adb.12645

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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