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Alkaloids with Immunosuppressive Activity from the Bark of Pausinystalia yohimbe.

Author: LiuJun-Jun, LiuYe, MengXiang-Gao, RuanHan-Li, XuHong-Zhe, YuHeng-Yi, ZhouMing

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

This study isolated and characterized ten new alkaloids, including two pairs of enantiomeric mixtures, from the bark of Pausinystalia yohimbe. Some of the isolates exhibited moderate immunosuppressive activity.
Paper Details　
Original Abstract of the Article :
Ten new alkaloids (1-10), including two pairs of enantiomeric mixtures (5a,b and 6a,b), and 15 known analogues (11-25) were obtained from the bark of Pausinystalia yohimbe. The structures of 1-25 were established by spectroscopic methods, and the absolute configurations of compounds 1-10 were resolv...See full text at original site
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引用元：
https://doi.org/10.1021/acs.jnatprod.8b00324

データ提供：米国国立医学図書館（NLM）

Exploring Immunosuppressive Alkaloids from Pausinystalia yohimbe

My dear fellow researchers, today we embark on a journey to the heart of the desert, where we will uncover the secrets of natural compounds with potential medicinal properties. This study focused on the bark of the Pausinystalia yohimbe tree, a botanical treasure trove brimming with alkaloids. The researchers isolated ten new alkaloids and fifteen known analogues, with the goal of understanding their potential immunosuppressive effects.

Immunosuppressive Activity of Specific Alkaloids

The researchers investigated the in vitro immunosuppressive activity of selected alkaloids, focusing on their ability to inhibit T lymphocyte proliferation and B lymphocyte proliferation. The findings revealed that two specific alkaloids, compounds 11 and 16, exhibited moderate inhibition against both T and B lymphocyte proliferation. These results are akin to discovering a hidden spring in the desert – a source of potential therapeutic benefits for conditions related to immune system regulation.

Potential for Future Therapeutic Applications

This study sheds light on the potential of natural compounds, specifically alkaloids from the Pausinystalia yohimbe tree, to modulate the immune system. The moderate immunosuppressive activity observed in this study suggests that these alkaloids could have potential therapeutic applications in conditions involving immune dysregulation. However, more research is necessary to fully understand the mechanisms of action and to explore their potential for treating various immune-mediated diseases.

Dr.Camel's Conclusion

This study serves as a reminder that the vast and unexplored desert of nature holds numerous treasures, some of which may hold the key to unlocking new therapeutic avenues for treating a variety of ailments. The potential of these alkaloids to modulate the immune system opens up intriguing possibilities for future research and development.

Date :
  1. Date Completed 2019-11-14
  2. Date Revised 2019-11-14
Further Info :

Pubmed ID

30059216

DOI: Digital Object Identifier

10.1021/acs.jnatprod.8b00324

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Article Analysis
・Effective treatment of yohimbe
SNS
PICO Info
in preparation
Languages

English

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