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Glasdegib in combination with cytarabine and daunorubicin in patients with AML or high-risk MDS: Phase 2 study results.
Author: ArellanoMartha, ChanGeoffrey, CortesJorge E, DeAngeloDaniel J, Douglas LairdA, Douglas SmithB, MaWeidong Wendy, MerchantAkil, Naveed ShaikM, O'ConnellAshleigh, OehlerVivian G, PollyeaDaniel A, RobakTadeusz, SchroederMark A, SekeresMikkael A, WangEunice S, ZeremskiMirjana
Original Abstract of the Article :
Glasdegib is a Hedgehog pathway inhibitor. This ongoing, open-label, phase 2 study (NCT01546038) evaluated glasdegib plus cytarabine/daunorubicin in patients with untreated acute myeloid leukemia (AML) or high-risk myelodysplastic syndromes (MDS). Patients received glasdegib 100 mg orally, once dail...See full text at original site
Dr.Camel's Paper Summary Blogラクダ博士について
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引用元:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6221102/
データ提供:米国国立医学図書館(NLM)
Glasdegib: A Potential New Weapon in the Fight Against AML and High-Risk MDS
This study investigates the effectiveness of glasdegib, a hedgehog pathway inhibitor, in combination with standard chemotherapy for treating patients with acute myeloid leukemia (AML) and high-risk myelodysplastic syndromes (MDS). The research explores a novel approach to treating these aggressive blood cancers, seeking to improve patient outcomes and potentially offer a new treatment option. The study found that glasdegib combined with chemotherapy showed promising clinical activity in patients, with a significant percentage achieving complete remission. This research offers valuable insights into the potential of glasdegib as a new therapeutic agent for AML and high-risk MDS, highlighting its potential for improving patient outcomes.
Glasdegib: A Promising New Avenue for AML and High-Risk MDS Treatment
This study provides a glimmer of hope for patients with AML and high-risk MDS, two aggressive blood cancers that often have limited treatment options. The study's findings suggest that glasdegib, a hedgehog pathway inhibitor, may be a valuable addition to current treatment regimens, potentially improving patient outcomes. It offers a new avenue for combating these diseases and could lead to better survival rates and quality of life for patients.
A New Frontier in Blood Cancer Treatment: Exploring Targeted Therapies
This research highlights the importance of exploring targeted therapies for blood cancers. The study demonstrates the potential of glasdegib, a hedgehog pathway inhibitor, to effectively target specific pathways within cancer cells. It's a reminder that as we continue to unravel the complexities of cancer biology, we can develop new and innovative treatments that are more effective and less toxic for patients. This study, like a caravan discovering a new trade route in the desert, offers a promising path for improving the treatment of blood cancers.
Dr.Camel's Conclusion
This study provides a roadmap for potential new treatments for AML and high-risk MDS. The study’s findings suggest that glasdegib could be a valuable asset in the fight against these blood cancers. Like a camel navigating a challenging landscape, we must continuously seek new and innovative approaches to treat these diseases and improve patient outcomes.
Date :
- Date Completed 2019-08-19
- Date Revised 2021-01-09
Further Info :
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