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Patient considerations in the management of gout and role of combination treatment with lesinurad.

Author: ClausLiza W, SaseenJoseph J

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Overview

Gout, a common rheumatic disease, is becoming more prevalent. While new treatment guidelines and drugs have emerged, gout often remains poorly controlled, leading to reduced quality of life and increased healthcare use. Urate-lowering therapy is key to preventing gout flare-ups and tophi (urate crystal deposits). Xanthine oxidase inhibitors are often first-line, followed by uricosurics like lesinurad. This review discusses gout management, including the potential for combination therapies to achieve treatment goals, and highlights lesinurad as a newer treatment option.
Paper Details　
Original Abstract of the Article :
Gouty arthritis is one of the most common rheumatic diseases, and the prevalence continues to rise, which is likely related to increased incidence of comorbidities, lifestyle factors, and suboptimal utilization of urate-lowering therapy. In recent years, multiple new guidelines have been published a...See full text at original site
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引用元：
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6054769/

データ提供：米国国立医学図書館（NLM）

Gout: A Common and Often Under-Treated Condition

Gout, a painful inflammatory condition that affects the joints, is a common ailment. This research discusses the management of gout, focusing on the importance of achieving and maintaining target serum urate levels. The authors emphasize the role of urate-lowering therapy in preventing recurrent gout attacks and resolving tophi, which are deposits of uric acid crystals. They highlight the benefits of combination therapy, including the use of lesinurad, a novel uricosuric agent. This research provides valuable information on the management of gout and the importance of achieving target urate levels.

Targeting Urate Levels: A Key to Effective Gout Management

The research emphasizes the importance of achieving and maintaining target serum urate levels in the management of gout. It highlights the role of urate-lowering therapy in preventing recurrent attacks and resolving tophi. This research emphasizes the importance of comprehensive gout management, including lifestyle modifications, urate-lowering medications, and prompt treatment of acute gout attacks.

Managing Gout: A Multifaceted Approach

This research highlights the importance of a comprehensive approach to managing gout, which includes lifestyle modifications, urate-lowering medications, and prompt treatment of acute gout attacks. It encourages individuals with gout to consult with their healthcare providers to develop a personalized management plan.

Dr. Camel's Conclusion

This research underscores the importance of comprehensive gout management, including lifestyle modifications, urate-lowering medications, and prompt treatment of acute gout attacks. It emphasizes the need for achieving and maintaining target serum urate levels to prevent recurrent attacks and resolve tophi.
Date :
  1. Date Completed n.d.
  2. Date Revised 2020-09-30
Further Info :

Pubmed ID

30140163

DOI: Digital Object Identifier

PMC6054769

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Article Analysis
・Effects of lesinurad
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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