Sustained Viral Response in Genotype 4 Chronic Hepatitis C Virus-infected Children and Adolescents Treated With Sofosbuvir/Ledipasvir.

Author: AbdullatifHala, BaroudySherif, El-KaraksyHanaa, El-KoofyNehal, El-RazikyMona S, El-ShabrawiMortada, GhitaHaytham, GhobrialCarolyne, MogahedEngy Adel, OkashaSawsan

Paper Details 
Original Abstract of the Article :
Recently, direct acting antivirals (DAAs), sofosbuvir (SOF) combined with ledipasvir (LED), were approved for treatment of hepatitis C virus (HCV)-infected children 12 years of age and older or weighting at least 35 kg for all HCV genotypes. The aim of this study was to assess the safety and efficac...See full text at original site
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引用元:
https://doi.org/10.1097/MPG.0000000000002101

データ提供:米国国立医学図書館(NLM)

Sofosbuvir/Ledipasvir: A Powerful Weapon Against Genotype 4 HCV in Children and Adolescents

Hepatitis C virus (HCV) infection can be a challenging condition, particularly in children and adolescents. This research explores the efficacy and safety of the direct-acting antiviral (DAA) combination sofosbuvir (SOF) and ledipasvir (LED) in treating genotype 4 HCV-infected Egyptian children and adolescents. The study evaluates the sustained viral response (SVR) achieved with this treatment regimen, highlighting its potential for effectively managing HCV infection in this population. This research contributes to the growing body of knowledge on the treatment of HCV infection in children and adolescents, offering valuable insights into the effectiveness of DAAs in this population.

Sofosbuvir/Ledipasvir: A Beacon of Hope in the Desert of HCV Infection

This study demonstrates the significant efficacy of SOF/LED in achieving SVR in genotype 4 HCV-infected children and adolescents. The research highlights the potential of this treatment regimen to effectively clear the virus and potentially prevent the long-term complications associated with chronic HCV infection. This research offers a promising treatment option for children and adolescents with HCV infection, providing hope for a cure and a healthier future.

Finding a Cure: A Desert Oasis of Healing

Just as a desert traveler seeks a source of water, individuals with HCV infection seek a cure. This research highlights the importance of ongoing research and development of new and effective antiviral therapies to treat HCV infection, particularly in children and adolescents. This study encourages further research to expand our understanding of DAAs and optimize their use for achieving SVR in diverse patient populations, ultimately leading to a world free from the burden of HCV infection.

Dr.Camel's Conclusion

This study provides promising evidence for the efficacy and safety of SOF/LED in treating genotype 4 HCV infection in children and adolescents. The research highlights the potential of this treatment regimen to achieve SVR and potentially prevent the long-term complications associated with chronic HCV infection. This study underscores the importance of ongoing research and development of new and effective therapies for HCV infection, particularly in vulnerable populations like children and adolescents, ultimately leading to a world free from the burden of this debilitating disease.

Date :
  1. Date Completed 2019-11-25
  2. Date Revised 2020-12-09
Further Info :

Pubmed ID

30216203

DOI: Digital Object Identifier

10.1097/MPG.0000000000002101

Related Literature

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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