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Cannabidiol prevents haloperidol-induced vacuos chewing movements and inflammatory changes in mice via PPARγ receptors.

Author: CunhaThiago M, Del BelElaine A, GuimarãesFrancisco S, PradoDouglas S, Raisman-VozariRita, Sepulveda-DiazJulia E, SonegoAndreza B, TirapelliCarlos R, ValeGabriel T

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

This study investigated the effects of cannabidiol (CBD) on orofacial dyskinesia, oxidative stress, and inflammatory changes induced by chronic haloperidol administration in mice. CBD was found to prevent haloperidol-induced orofacial dyskinesia, reduce microglial activation and inflammatory mediators, and attenuate oxidative stress. These effects were mediated by PPARγ receptors.
Paper Details　
Original Abstract of the Article :
The chronic use of drugs that reduce the dopaminergic neurotransmission can cause a hyperkinetic movement disorder called tardive dyskinesia (TD). The pathophysiology of this disorder is not entirely understood but could involve oxidative and neuroinflammatory mechanisms. Cannabidiol (CBD), the majo...See full text at original site
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ラクダ博士は、Health Journal が論文の内容を分かりやすく解説するために作成した架空のキャラクターです。
難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。

* ラクダ博士による解説は、あくまで論文の要点をまとめたものであり、原論文の完全な代替となるものではありません。詳細な内容については、必ず原論文をご参照ください。
* ラクダ博士は架空のキャラクターであり、実際の医学研究者や医療従事者とは一切関係がありません。
* 解説の内容は Health Journal が独自に解釈・作成したものであり、原論文の著者または出版社の見解を反映するものではありません。


引用元：
https://doi.org/10.1016/j.bbi.2018.09.014

データ提供：米国国立医学図書館（NLM）

Cannabidiol: A Potential Treatment for Tardive Dyskinesia

This research explores the potential therapeutic effects of cannabidiol (CBD) for tardive dyskinesia (TD), a movement disorder that can occur as a side effect of certain antipsychotic medications. The study investigated whether CBD could prevent the development of orofacial dyskinesia, a common symptom of TD, in mice treated with haloperidol, a typical antipsychotic. The study found that CBD effectively prevented haloperidol-induced orofacial dyskinesia, likely by activating PPARγ receptors and attenuating neuroinflammatory changes in the striatum.

CBD: A Promising Avenue for TD Treatment

This research suggests that CBD may offer a potential therapeutic avenue for TD. The study's findings suggest that CBD's effects are mediated by PPARγ receptors, a type of nuclear receptor involved in regulating inflammation and other cellular processes. This is like a desert oasis providing relief from the harsh conditions, CBD may offer a haven for those suffering from TD.

Seeking Relief from TD: Talking to Your Doctor

If you are experiencing symptoms of TD, it's important to consult with a healthcare professional. They can help you understand the underlying causes of your condition and discuss potential treatment options. Just as a wise camel seeks shelter from the scorching sun, you should seek guidance from a qualified medical expert for your health concerns.

Dr. Camel's Conclusion

This study offers a glimmer of hope for individuals struggling with TD, suggesting that CBD may provide a safe and effective treatment option. It's like discovering a hidden spring in the desert, bringing relief and rejuvenation to those in need.
Date :
  1. Date Completed 2019-09-10
  2. Date Revised 2019-09-10
Further Info :

Pubmed ID

30217539

DOI: Digital Object Identifier

10.1016/j.bbi.2018.09.014

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Languages

English

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