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Overexpression of SENP1 reduces the stemness capacity of osteosarcoma stem cells and increases their sensitivity to HSVtk/GCV.

Author: BianXiyun, LiLili, LiYanxia, LiuFengting, LiuXiaozhi, MaXiaofang, WangGuowen, ZhangDianying

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

This study investigated the role of SUMO1 specific peptidase 1 (SENP1) in osteosarcoma stem cells. SENP1 expression was significantly lower in osteosarcoma tissues and cell lines, particularly in stem cells compared to non-cancer stem cells. Overexpression of SENP1 decreased stemness but only slightly induced apoptosis, minimizing side effects on normal precursor cells. This led to increased sensitivity of osteosarcoma stem cells to chemotherapeutic drugs, potentially reducing the required dose and side effects.
Paper Details　
Original Abstract of the Article :
Osteosarcoma stem cells are able to escape treatment with conventional chemotherapeutic drugs, as the majority of them are in a quiescent state. Recent reports have suggested that small ubiquitin‑like modifiers (SUMOs) serve important roles in the maintenance of cancer stem cell stemness. Therefore,...See full text at original site
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引用元：
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6192779/

データ提供：米国国立医学図書館（NLM）

SENP1: A Key Player in Osteosarcoma Stem Cell Control

This study investigates the role of SUMO1 specific peptidase 1 (SENP1) in the regulation of osteosarcoma stem cells. The authors found that SENP1 expression is significantly decreased in osteosarcoma tissues and cell lines, particularly in osteosarcoma stem cells. They demonstrate that overexpression of SENP1 reduces the stemness capacity of these cells and increases their sensitivity to herpes simplex virus 1 thymidine kinase gene in combination with ganciclovir, suggesting a potential strategy for improving the effectiveness of chemotherapeutic agents.

Targeting Osteosarcoma Stem Cells: A New Approach to Cancer Treatment

This research introduces a novel approach to targeting osteosarcoma stem cells, a key contributor to the recurrence of this aggressive cancer. It's like finding a hidden oasis in the desert; targeting these stem cells could provide a new avenue for effective treatment. This study underscores the importance of understanding the molecular mechanisms underlying cancer stem cell regulation to develop more effective therapies.

SENP1: A Potential Weapon in the Fight Against Osteosarcoma

This study reveals the potential of SENP1 as a therapeutic target for osteosarcoma. It's like discovering a hidden spring in the desert; targeting SENP1 could offer a new weapon in the fight against this challenging cancer. Further research is needed to explore the clinical implications of these findings and develop targeted therapies based on SENP1 modulation.

Dr.Camel's Conclusion

This research offers a promising new avenue for targeting osteosarcoma stem cells. It's like finding a hidden path through a vast desert; by understanding the role of SENP1, we can unlock new possibilities for treating this aggressive cancer. This study highlights the power of scientific exploration in uncovering novel strategies for combating disease.

Date :
  1. Date Completed 2019-01-28
  2. Date Revised 2019-01-28
Further Info :

Pubmed ID

30226577

DOI: Digital Object Identifier

PMC6192779

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・Side Effects of ganciclovir
SNS
PICO Info
in preparation
Languages

English

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