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Heat shock pretreatment of mesenchymal stem cells for inhibiting the apoptosis of ovarian granulosa cells enhanced the repair effect on chemotherapy-induced premature ovarian failure.

Author: ChenXiaoying, FuXiafei, LiXinran, WangQing, WangQingru, XieJiaxin

Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

This study investigated the repair effect of heat shock (HS) mesenchymal stem cells (MSCs) on chemotherapy-induced premature ovarian failure (POF). Previous research showed that bone marrow-derived MSCs can partially repair ovarian damage. This study aimed to demonstrate the potential of HS MSCs in repairing ovarian structure and function after chemotherapy.
Paper Details　
Original Abstract of the Article :
Premature ovarian failure (POF) is a severe complication associated with chemotherapy for female patients of childbearing age. A previous study has shown that bone marrow-derived mesenchymal stem cells (MSCs) can partially repair the damaged ovarian structure and function following chemotherapy. Hea...See full text at original site
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引用元：
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6158904/

データ提供：米国国立医学図書館（NLM）

The Desert of Ovarian Failure: A Stem Cell Oasis for Repair

The desert of reproductive health can be a challenging landscape, particularly when it comes to premature ovarian failure (POF), a serious complication associated with chemotherapy. This study explores the potential of bone marrow-derived mesenchymal stem cells (MSCs), a type of stem cell known for its regenerative properties, in repairing damage to the ovaries caused by chemotherapy.

Navigating the Desert: Harnessing the Power of Stem Cells

The researchers investigated the effects of heat-shocked MSCs on chemotherapy-induced POF in a pre-clinical model. They found that heat shock pretreatment enhanced the survival of MSCs and improved their ability to repair damaged ovarian tissue. These findings suggest that heat-shocked MSCs may hold promise for treating chemotherapy-induced POF.

Finding Hope in the Desert: A New Treatment for Ovarian Failure

This study offers hope for patients facing chemotherapy-induced POF. It suggests that stem cell therapy, particularly with heat-shocked MSCs, may offer a viable option for restoring ovarian function and preserving fertility. As we journey through the desert of reproductive health, let's embrace the potential of regenerative medicine to provide new treatments for challenging conditions.

Dr.Camel's Conclusion

The desert of ovarian failure can be a desolate place. This study suggests that stem cell therapy, like a refreshing oasis, may offer hope for restoring fertility and reproductive health. As we continue to explore the potential of stem cells, let's embrace the possibility of finding new and effective treatments for those facing challenging reproductive health conditions.

Date :
  1. Date Completed 2019-03-14
  2. Date Revised 2019-03-14
Further Info :

Pubmed ID

30257708

DOI: Digital Object Identifier

PMC6158904

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Languages

English

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