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Titration of pulmonary arterial hypertension therapeutics: Experience-based recommendations.

Author: BerngardSamuel Clark, DuncanMaribeth, FernandesTimothy, KingmanMartha, LombardiSandra

Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
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Overview

This article provides recommendations for dose titration schemes for pulmonary arterial hypertension (PAH) medications that require individualized dosing in adult patients. It emphasizes the importance of careful titration to maximize therapeutic effectiveness while minimizing side effects, considering different routes of administration and potential challenges they present. The article stresses the critical role of patient education, frequent monitoring, and treatment adherence for optimal outcomes.
Paper Details　
Original Abstract of the Article :
The availability of new medications has improved exercise capacity, enhanced quality of life, and extended time to clinical worsening in patients with pulmonary arterial hypertension (PAH). For many of these medications, careful individualized dose titration is required to maximize therapeutic effec...See full text at original site
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引用元：
https://doi.org/10.1016/j.rmed.2018.09.002

データ提供：米国国立医学図書館（NLM）

Titrating Pulmonary Arterial Hypertension Therapeutics: A Guide for Clinicians

The treatment of pulmonary arterial hypertension (PAH) is a complex journey, often involving a careful titration of medications to maximize therapeutic efficacy while minimizing side effects. This article offers experience-based recommendations for dose titration schemes for PAH medications, including agents acting on the endothelin-1 pathway, prostacyclin pathway, and nitric oxide pathway. The authors emphasize the importance of individualized dosing, considering specific routes of administration, potential challenges associated with each route, and the need for careful management of side effects. The article provides valuable guidance for clinicians navigating the challenges of managing PAH medication therapy.

Individualized Dose Titration: A Key to Effective PAH Management

This article highlights the importance of individualized dose titration for PAH medications, emphasizing the need for careful monitoring and management of side effects. The authors provide practical recommendations for clinicians navigating the complexities of PAH medication therapy, emphasizing the importance of communication, patient education, and adherence to treatment plans. The article serves as a valuable guide for clinicians, promoting optimal medication usage and patient health.

Navigating the Desert of PAH Medication Therapy

This article offers valuable guidance for clinicians navigating the challenges of managing PAH medication therapy. The authors provide practical recommendations for dose titration schemes, considering specific routes of administration, potential challenges associated with each route, and the need for careful management of side effects. The article emphasizes the importance of individualized dosing, open communication, and patient education, serving as a vital tool for promoting optimal medication usage and patient health.

Dr.Camel's Conclusion

This article provides practical recommendations for clinicians navigating the challenges of managing PAH medication therapy. The authors emphasize the importance of individualized dose titration, considering specific routes of administration, potential challenges associated with each route, and the need for careful management of side effects. The article serves as a valuable guide for clinicians, promoting optimal medication usage and patient health.

Date :
  1. Date Completed 2019-10-02
  2. Date Revised 2019-10-02
Further Info :

Pubmed ID

30261985

DOI: Digital Object Identifier

10.1016/j.rmed.2018.09.002

SNS
PICO Info
in preparation
Languages

English

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