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Isosorbide and nifedipine for Chagas' megaesophagus: A systematic review and meta-analysis.

Author: Borges MigliavacaCelina, ColpaniVerônica, FalavignaMaicon, Nascimento CruzLuciane, Oliveira DantasRoberto, René Pinto de Sousa MiguelSandro, SteinCinara

Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Overview

Both isosorbide and nifedipine can effectively reduce esophageal symptoms in patients with Chagas' megaesophagus. Isosorbide appears to be more effective, while nifedipine has a better tolerability profile.
Paper Details　
Original Abstract of the Article :
BACKGROUND: Chagas disease is a neglected tropical disease. About 6 to 8 million people are chronically infected and 10% to 15% develop irreversible gastrointestinal disorders, including megaesophagus. Treatment focuses on improving symptoms, and isosorbide and nifedipine may be used for this purpos...See full text at original site
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引用元：
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6179300/

データ提供：米国国立医学図書館（NLM）

Isosorbide and Nifedipine for Chagas' Megaesophagus: A Systematic Review and Meta-Analysis

This study embarks on a systematic review and meta-analysis of the effectiveness of isosorbide and nifedipine, two medications commonly used for treating Chagas' megaesophagus, a debilitating condition caused by a parasitic infection. The analysis included eight studies, combining results from randomized controlled trials and observational studies. The researchers found that both isosorbide and nifedipine were effective in reducing esophageal symptoms, with isosorbide showing greater efficacy but nifedipine demonstrating better tolerability.

Isosorbide and Nifedipine: Potential Therapeutic Options for Chagas' Megaesophagus

This systematic review and meta-analysis suggest that both isosorbide and nifedipine can be effective in treating Chagas' megaesophagus. Isosorbide, while showing greater efficacy, may be associated with more side effects. Nifedipine, on the other hand, appears to be better tolerated.

Navigating the Complexities of Chagas' Disease

This study underscores the need for further research into effective treatments for Chagas' megaesophagus. The limited available evidence suggests that both isosorbide and nifedipine can be valuable therapeutic options, but more studies are needed to optimize treatment strategies and minimize side effects.

Dr. Camel's Conclusion

This comprehensive review provides valuable insights into the treatment of Chagas' megaesophagus. While the available evidence suggests that both isosorbide and nifedipine can be effective, more research is needed to refine treatment protocols and provide optimal care for patients with this debilitating condition.
Date :
  1. Date Completed 2019-01-14
  2. Date Revised 2023-09-28
Further Info :

Pubmed ID

30265663

DOI: Digital Object Identifier

PMC6179300

Related Literature

Article Analysis
・Effective treatment of chagas disease
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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