Evaluation of long-term safety, tolerability, and behavioral outcomes with adjunctive rufinamide in pediatric patients (≥1 to <4 years old) with Lennox-Gastaut syndrome: Final results from randomized study 303.

Author: ArzimanoglouAlexis, BibbianiFrancesco, DhaddaShobha, FerreiraJose, KumarDinesh, OlhayeOmar, SatlinAndrew

Paper Details 
Original Abstract of the Article :
OBJECTIVE: Evaluate the long-term safety, tolerability, and behavioral effects of adjunctive rufinamide in pediatric patients (≥1 to <4 years old) with inadequately controlled seizures associated with Lennox-Gastaut syndrome (LGS). METHODS: Study 303 (ClinicalTrials.gov identifier NCT01405053) was ...See full text at original site
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引用元:
https://doi.org/10.1016/j.ejpn.2018.09.010

データ提供:米国国立医学図書館(NLM)

Rufinamide: A Potential Oasis in the Desert of Lennox-Gastaut Syndrome

Lennox-Gastaut syndrome (LGS), a severe form of epilepsy, is a challenging condition, much like a sandstorm that disrupts the peace of the desert. This study investigates the long-term safety, tolerability, and behavioral effects of rufinamide, an antiepileptic drug, in children with LGS.

Navigating the Desert of Epilepsy: A Quest for Effective Treatment

The study found that rufinamide was well tolerated in children with LGS, with comparable behavioral outcomes to other antiepileptic drugs. This is like finding a sturdy camel to navigate the difficult terrain, providing a reliable and safe way to move forward. The study highlights the potential of rufinamide as a valuable treatment option for children with this challenging condition.

Finding a Path Through the Desert of Epilepsy: A Glimpse of Hope

This study offers a glimmer of hope for children with LGS, demonstrating the potential of rufinamide to provide a safe and effective treatment option. It emphasizes the importance of continued research to better understand the long-term effects of this drug and to develop even more effective treatments. This is like discovering a new oasis in the desert, providing a source of relief and a path towards a brighter future.

Dr. Camel's Conclusion

Lennox-Gastaut syndrome is a formidable challenge, but research continues to offer new paths to treatment. This study highlights the potential of rufinamide as a safe and well-tolerated option for children with LGS. It's like finding a sturdy camel to navigate the difficult terrain of epilepsy, offering a chance to travel through the desert with greater ease and confidence.

Date :
  1. Date Completed 2019-04-05
  2. Date Revised 2022-04-08
Further Info :

Pubmed ID

30309816

DOI: Digital Object Identifier

10.1016/j.ejpn.2018.09.010

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