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[When drugs induce cutaneous lupus erythematosus].

Author: BygumAnette, SkovmøllerKathrine Balslev

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Overview

Drug-induced subacute cutaneous lupus erythematosus (DI-SCLE) is a rare skin condition that can be triggered by certain medications. About 20% of SCLE cases are thought to be drug-induced. While there are no specific diagnostic criteria for DI-SCLE, some factors suggest a possible diagnosis, such as the presence of anti-Ro/SSA antibodies, skin lesions, and a widespread rash. Commonly implicated drugs include proton pump inhibitors, terbinafine, thiazides, and chemotherapeutics.
Paper Details　
Original Abstract of the Article :
Drug-induced subacute cutaneous lupus erythematosus (DI-SCLE) is defined as an adverse reaction to continuous use of a culprit drug. The reaction resolves upon drug withdrawal. More than 50 drugs have been linked to DI-SCLE, and it is estimated, that around 20% of the SCLE cases are drug-induced. Th...See full text at original site
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引用元：
https://pubmed.ncbi.nlm.nih.gov/30327081

データ提供：米国国立医学図書館（NLM）

When Drugs Trigger Skin Reactions: Drug-Induced Cutaneous Lupus Erythematosus

[Drug-induced subacute cutaneous lupus erythematosus (DI-SCLE)] is a fascinating and complex area of [medicine]. This study explores the intricate relationship between [drug use] and the development of [cutaneous lupus erythematosus]. The researchers investigated the characteristics and triggers of [DI-SCLE], shedding light on the diverse medications that can contribute to its development.

A Complex and Multifaceted Condition

The study highlights the complexity of [DI-SCLE], emphasizing the need for careful consideration of the [drug history] of patients presenting with [cutaneous lupus erythematosus]. The identification of [anti-Ro/SSA antibodies], [erosive/bullous lesions], and [erythema multiforme/toxic epidermal necrolysis-like lesions] can be important indicators of this condition.

The Importance of Prompt Recognition and Management

The findings emphasize the crucial role of [prompt recognition] and [timely management] in cases of [DI-SCLE]. Identifying and removing the [culprit drug] is essential for resolving the condition. This study serves as a reminder for clinicians to remain vigilant about the potential for [drug-induced reactions] and to consider [DI-SCLE] in the differential diagnosis of [cutaneous lupus erythematosus].

Dr. Camel's Conclusion

The delicate balance between the benefits and risks of [drug therapy] is a constant challenge in [medicine]. This study underscores the importance of understanding the potential for [drug-induced reactions], ensuring we can provide safe and effective care for our patients. Just as a camel can navigate a treacherous desert landscape, we must carefully navigate the complex world of drug interactions and potential side effects.

Date :
  1. Date Completed 2019-12-20
  2. Date Revised 2019-12-20
Further Info :

Pubmed ID

30327081

DOI: Digital Object Identifier

V04180277

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