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Aquaporins Alteration Profiles Revealed Different Actions of Senna, Sennosides, and Sennoside A in Diarrhea-Rats.

Author: CaoYixin, ChengYing, HeYing, LiJing, QiaoBoling, QuLejing, WeiCong, ZhangHuiqin

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

Senna is a popular laxative, but its long-term use can be risky for patients with kidney or liver problems. This study found that senna extract led to significant weight loss and increased organ size in rats, particularly in the kidneys and liver. Sennosides, the active ingredient in senna, were shown to have a strong laxative effect but also suppressed aquaporins, which are water channels in the colon. These findings suggest that chronic senna use requires caution in individuals with pre-existing kidney or liver conditions.
Paper Details　
Original Abstract of the Article :
Senna and its main components sennosides are well-known effective laxative drugs and are used in the treatment of intestinal constipation in the world. Their potential side effects have attracted more attention in clinics but have little scientific justification. In this study, senna extract (SE), s...See full text at original site
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引用元：
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6213963/

データ提供：米国国立医学図書館（NLM）

Senna: A Journey Through the Digestive Tract

Senna, like a trusty guide through a vast desert, has long been used to address constipation. This study explores the intricate workings of senna and its main components, sennosides, on the digestive system. It aims to shed light on the potential side effects of these laxative drugs, a hidden oasis in the desert of medicinal knowledge.

Researchers used senna extract (SE), sennosides (SS), and sennoside A (SA) to induce diarrhea in rats, creating a model to understand the effects of these compounds. They then carefully analyzed the rats' behaviors, clinical signs, organ indices, and the expression of various aquaporins (AQPs), which are water channel proteins that play a crucial role in regulating water movement across cell membranes.

Unveiling the Complexities of Senna

The study discovered that SE treatment had a significant impact on the kidneys and livers of the rats, suggesting a potential for toxicity in these organs. SS, on the other hand, showed a strong laxative effect primarily within the colon. The study highlights the importance of understanding the distinct actions of these compounds and the potential for organ-specific effects.

Navigating the Oasis of Senna Treatment

This research underscores the need for caution when using senna-based products, especially in individuals with kidney or liver conditions. It is crucial to recognize that while senna can be a helpful guide through the desert of constipation, it also requires a discerning eye for potential side effects.

Dr. Camel's Conclusion

This study offers valuable insights into the intricate interplay between senna, its components, and the digestive system. By mapping the pathways of these compounds, the study helps us understand their potential benefits and risks. As we explore the vast desert of medicinal knowledge, it is crucial to remain vigilant about the potential side effects of even seemingly benign remedies.
Date :
  1. Date Completed 2019-01-28
  2. Date Revised 2023-10-04
Further Info :

Pubmed ID

30336596

DOI: Digital Object Identifier

PMC6213963

Related Literature

Article Analysis
・Side Effects of senna
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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