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In vitro and in vivo antidiabetic activity of isolated fraction of Prosopis cineraria against streptozotocin-induced experimental diabetes: A mechanistic study.

Author: AryaDharmendra, BhagourKiran, DobhalMahabeer Prasad, GuptaR S, ParasherPradeep, SoniLokesh Kumar

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

Diabetes mellitus is a growing health concern. This study investigated the antidiabetic activity of P. cineraria stem bark extract (CfPc) in a rat model of diabetes. CfPc was found to lower blood glucose levels, improve insulin sensitivity, and reduce lipid levels. It also inhibited α-amylase activity.
Paper Details　
Original Abstract of the Article :
A rapidly increasing incidence of Diabetes mellitus throughout the world is a major concern in both developed and developing countries and the drawbacks associated with currently available treatments led to switching researcher's attention towards naturopathy. Since ancient time, herbal plants have ...See full text at original site
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引用元：
https://doi.org/10.1016/j.biopha.2018.09.099

データ提供：米国国立医学図書館（NLM）

Prosopis cineraria: A Desert Plant with Potential Antidiabetic Properties

Diabetes mellitus is a growing global health crisis, and finding effective and safe treatment options is crucial. This study, like a camel seeking a valuable oasis in the desert of diabetes research, investigates the antidiabetic properties of Prosopis cineraria, a desert plant with traditional medicinal uses.

The researchers isolated various compounds from the stem bark of Prosopis cineraria and evaluated their antidiabetic activity in streptozotocin-induced diabetic rats.

The study found that the chloroform fraction of Prosopis cineraria (CfPc) significantly lowered blood glucose levels, glycosylated hemoglobin, and restored body weight, liver glycogen content, and serum insulin level in diabetic rats. The study also found that CfPc inhibited α-amylase enzyme activity, suggesting its potential in managing postprandial hyperglycemia.

A Promising Natural Remedy for Diabetes

This study highlights the potential of Prosopis cineraria as a natural source of antidiabetic compounds. The findings suggest that CfPc could be a valuable addition to the management of diabetes, offering multiple modes of action, including antihyperglycemic, hypolipidemic, and insulin secretory effects.

Exploring the Medicinal Properties of Desert Plants

This study underscores the importance of exploring the medicinal properties of plants, particularly those found in harsh environments like deserts. The findings suggest that Prosopis cineraria could offer a valuable natural remedy for diabetes and related complications.

Dr.Camel's Conclusion

This study provides encouraging evidence for the antidiabetic potential of Prosopis cineraria. The findings suggest that this desert plant could offer a valuable natural remedy for diabetes, providing multiple modes of action to manage blood glucose levels and improve overall health.

Date :
  1. Date Completed 2019-03-01
  2. Date Revised 2022-12-07
Further Info :

Pubmed ID

30372801

DOI: Digital Object Identifier

10.1016/j.biopha.2018.09.099

SNS
PICO Info
in preparation
Languages

English

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