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Progesterone, 5a-dihydropogesterone and allopregnanolone's effects on seizures: A review of animal and clinical studies.

Author: BurnhamW McIntyre, WuYinhao Violet

ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

Progesterone and its metabolites, allopregnanolone and 5α-dihydroprogesterone, have demonstrated anti-seizure effects in animal models and clinical trials. These effects are likely mediated by modulation of GABA receptors and other membrane receptors. While promising for the development of new anti-seizure drugs, their endocrine effects need to be mitigated through rational drug design.
Paper Details　
Original Abstract of the Article :
The anti-seizure effects of progesterone family compounds have long been known. Over the years, however, most studies have focused on progesterone and on its secondary metabolite allopregnanolone (ALLO), with less attention being paid to its primary metabolite 5a-dihydroprogesterone (DHP). Here we r...See full text at original site
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引用元：
https://doi.org/10.1016/j.seizure.2018.10.012

データ提供：米国国立医学図書館（NLM）

Progesterone and its Metabolites: A Desert Oasis for Seizure Relief

The world of epilepsy research is like a vast desert, with researchers constantly searching for new ways to tame the unpredictable storms of seizures. This review article delves into the intriguing therapeutic potential of progesterone and its neuroactive metabolites - 5a-dihydroprogesterone (DHP) and allopregnanolone (ALLO). They are like hidden oases offering potential relief from the relentless heat of seizures.

Progesterone Family: A Potential Oasis for Seizures

The study found that progesterone and its metabolites, DHP and ALLO, have demonstrated seizure-suppressing effects in various animal models, with the exception of absence seizures. Progesterone and ALLO have also shown promise in clinical trials. The study highlighted the potential benefits of progesterone therapy for women with premenstrual exacerbations of seizures. Additionally, ALLO's C3 methyl analog ganaxolone is currently being explored as a potential anti-seizure drug. While these compounds offer hope, potential drawbacks include their endocrine effects.

Navigating the Desert of Epilepsy Treatment

The study provides valuable insights into the potential benefits of progesterone and its metabolites for seizure control. While further research is needed to fully understand their mechanism of action and mitigate potential side effects, these findings offer hope for developing novel therapies for epilepsy. As researchers, we continue to explore the vast desert of epilepsy, seeking to discover new oases of hope for those affected by this debilitating condition.

Dr.Camel's Conclusion

The study reveals the potential of progesterone and its metabolites in managing seizures. While further research is essential to optimize their use and address potential limitations, this study offers a beacon of hope in the relentless battle against epilepsy. We, as researchers, continue our journey through the desert of medical knowledge, seeking to discover new treatments and improve the lives of those affected by this challenging condition.

Date :
  1. Date Completed 2018-12-17
  2. Date Revised 2018-12-17
Further Info :

Pubmed ID

30391663

DOI: Digital Object Identifier

10.1016/j.seizure.2018.10.012

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Languages

English

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