Paper Details

  1. Home
  2. Paper Details

HCV genotype 1-6 NS3 residue 80 substitutions impact protease inhibitor activity and promote viral escape.

Author: BukhJens, FahnøeUlrik, GhanemLubna, GottweinJudith M, HumesDaryl, JensenSanne Brun, PedersenMartin Schou, PhamLong V, RamirezSantseharay, SchønningKristian, SerreStéphanie B N, TangQi

Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

This study investigated the effects of position-80-substitutions on fitness and PI-resistance for HCV genotypes 1-6.
Paper Details　
Original Abstract of the Article :
Protease inhibitors (PIs) are of central importance in the treatment of patients with chronic hepatitis C virus (HCV) infection. HCV NS3 protease (NS3P) position 80 displays polymorphisms associated with resistance to the PI simeprevir for HCV genotype 1a. We investigated the effects of position-80-...See full text at original site
Dr.Camel IconDr.Camel's Paper Summary Blogラクダ博士について

ラクダ博士は、Health Journal が論文の内容を分かりやすく解説するために作成した架空のキャラクターです。
難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。

* ラクダ博士による解説は、あくまで論文の要点をまとめたものであり、原論文の完全な代替となるものではありません。詳細な内容については、必ず原論文をご参照ください。
* ラクダ博士は架空のキャラクターであり、実際の医学研究者や医療従事者とは一切関係がありません。
* 解説の内容は Health Journal が独自に解釈・作成したものであり、原論文の著者または出版社の見解を反映するものではありません。


引用元：
https://doi.org/10.1016/j.jhep.2018.10.031

データ提供：米国国立医学図書館（NLM）

HCV NS3 Protease: A Challenging Oasis in Antiviral Treatment

Hepatitis C virus (HCV) is a major public health concern, and [protease inhibitors (PIs)] are crucial for treating chronic HCV infection. This research focuses on the impact of [NS3 residue 80 substitutions] on HCV genotype 1-6, which is associated with resistance to the PI [simeprevir].

The researchers investigated the effects of position-80 substitutions on viral fitness and PI-resistance in different HCV genotypes. They found that these substitutions could promote viral escape, potentially leading to treatment failure. Their analysis revealed the evolutionary mechanisms underlying viral escape mediated by pre-existing [Q80K].

Navigating the Shifting Sands of HCV Resistance

The study sheds light on the evolving nature of HCV resistance to PIs. It emphasizes the need for ongoing surveillance and development of new treatment strategies to overcome emerging resistance mechanisms.

Staying Ahead of the Curve in HCV Treatment

This research is a reminder that the fight against HCV is a constant battle. We need to stay vigilant and adapt our treatment strategies to overcome evolving challenges. It's a reminder that even in the desert of viral research, we must keep moving forward.

Dr.Camel's Conclusion

This research is like a desert oasis, providing a glimpse into the challenging landscape of HCV resistance. It highlights the need for constant vigilance and innovation in developing new treatments to combat this persistent foe.

Date :
  1. Date Completed 2020-09-22
  2. Date Revised 2020-09-22
Further Info :

Pubmed ID

30395912

DOI: Digital Object Identifier

10.1016/j.jhep.2018.10.031

Related Literature

Article Analysis
・Effects of simeprevir
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

This site uses cookies. Visit our privacy policy page or click the link in any footer for more information and to change your preferences.