Microbiological Profile of Sarecycline, a Novel Targeted Spectrum Tetracycline for the Treatment of Acne Vulgaris.

Author: AlvandiNancy, CritchleyIan, LinLynn-Yao, ZhanelGeorge

Paper Details 
Original Abstract of the Article :
Sarecycline is the first narrow-spectrum tetracycline-class antibiotic being developed for acne treatment. In addition to exhibiting activity against important skin/soft tissue pathogens, sarecycline exhibits targeted antibacterial activity against clinical isolates of <i>Cutibacterium acnes</i> In ...See full text at original site
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引用元:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6325184/

データ提供:米国国立医学図書館(NLM)

Sarecycline: A Narrow Path Through the Acne Desert

The [dermatology] field is a vast landscape, with acne being a common and often challenging terrain. This study focuses on sarecycline, a novel narrow-spectrum tetracycline antibiotic, designed to traverse the acne desert with precision. Sarecycline is a targeted weapon against the bacteria Cutibacterium acnes, a notorious inhabitant of the acne desert. The research team wanted to assess its effectiveness against C. acnes while minimizing collateral damage to the diverse and delicate ecosystems of the human body, like the gut microbiome. Their findings reveal that sarecycline successfully targets C. acnes while demonstrating reduced activity against other bacteria, suggesting a more targeted approach to combating acne.

Sarecycline: A Narrow Path Through the Acne Desert

The researchers discovered that sarecycline was significantly less active against certain bacteria in the gut microbiome compared to broad-spectrum tetracyclines, suggesting a potential advantage in reducing negative side effects, like those associated with gut dysbiosis. They also observed that C. acnes strains exhibited a low propensity for developing resistance to sarecycline, which is like finding a stable oasis in a desert prone to shifting sands. This research highlights the potential benefits of narrow-spectrum antibiotics in selectively targeting acne-causing bacteria, potentially minimizing disruptions to the delicate ecosystem of the human body.

Navigating the Acne Desert: A Targeted Approach

Sarecycline offers a promising new path through the acne desert, offering a targeted approach that may minimize collateral damage to the delicate ecosystems within the human body. This research suggests a potential shift in the way we approach acne, embracing a more targeted approach to combatting this challenging condition.

Dr.Camel's Conclusion

Sarecycline represents a potential oasis in the desert of acne treatment, offering a targeted and potentially gentler approach to combatting this prevalent skin condition. However, further exploration is needed to fully understand its long-term effects and potential for minimizing disruptions to the microbiome, ensuring a safe and effective journey through the acne desert.

Date :
  1. Date Completed 2020-01-28
  2. Date Revised 2020-03-09
Further Info :

Pubmed ID

30397052

DOI: Digital Object Identifier

PMC6325184

Related Literature

SNS
PICO Info
in preparation
Languages

English

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