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Inflammatory effects of atazanavir/ritonavir versus darunavir/ritonavir in treatment naïve, HIV-1-infected patients.

Author: , AntinoriAndrea, CarraraStefania, Cozzi LepriAlessandro, D'arminio MonforteAntonella, DentoneChiara, Di BiagioAntonio, FenoglioDaniela, FilaciGilberto, GiacomettiAndrea, LichtnerMiriam, MarchettiGiulia, SighinolfiLaura

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

There was little evidence for an association between antiretroviral regimens and modulation of vascular inflammatory and activation markers over one year of exposure. The analysis of soluble markers of inflammation in treatment-naive HIV-1-infected patients showed a difference in ox-LDL between the atazanavir/ritonavir and darunavir/ritonavir groups, but overall, antiretroviral regimens had generally poor efficiency in downregulating these markers.
Paper Details　
Original Abstract of the Article :
BACKGROUND: Limited studies have compared the impact of different antiretroviral regimens on soluble markers of inflammation with discordant results. METHODS: In this prospective study, treatment naïve HIV-1-infected patients were included if they started their current regimen with atazanavir/riton...See full text at original site
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引用元：
https://doi.org/10.1080/15284336.2018.1488453

データ提供：米国国立医学図書館（NLM）

Antiretroviral Regimens: Navigating the Desert of HIV-1 Infection

HIV-1 infection, a persistent threat to global health, can be likened to a treacherous desert journey, with the virus relentlessly challenging the body's immune system. This research investigates the potential impact of different antiretroviral regimens on inflammation in patients newly diagnosed with HIV-1. The authors compared the effects of atazanavir/ritonavir (ATV/r) and darunavir/ritonavir (DRV/r) on various markers of inflammation, such as IL-6, MCP-1, and ox-LDL. This study is like a caravan of camels, carefully comparing different routes through the desert, seeking to minimize the harmful effects of HIV-1 infection.

Antiretroviral Regimens: Minimizing Inflammation in HIV-1

The study suggests that while antiretroviral regimens can effectively suppress the virus, they may have varying impacts on inflammation. The findings reveal that ATV/r, compared to DRV/r, may be associated with higher levels of ox-LDL, a marker of oxidative stress. This information is crucial for understanding the potential long-term effects of different treatment options.

A Long and Winding Road: Managing HIV-1 Infection

This research underscores the importance of understanding the complex interplay between HIV-1 infection, antiretroviral therapy, and inflammation. By carefully evaluating the effects of different treatment regimens, we can potentially optimize care for individuals living with HIV-1 and promote better long-term health outcomes.

Dr. Camel's Conclusion

This research highlights the challenges of managing HIV-1 infection and the importance of individualizing treatment strategies. By carefully considering the potential impacts of different antiretroviral regimens, we can help individuals living with HIV-1 navigate this complex journey and achieve better health outcomes.

Date :
  1. Date Completed 2019-06-13
  2. Date Revised 2019-06-13
Further Info :

Pubmed ID

30422095

DOI: Digital Object Identifier

10.1080/15284336.2018.1488453

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SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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