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Multiple myeloma in central and northern Norway 1981-1982: a follow-up study of a randomized clinical trial of 5-drug combination therapy versus standard therapy.

Author: BjarkP, BondevikA, BullO, BurgessG, DehliO, HoelS, JaegerS, Kildahl-AndersenO, KvambeV, MürerF

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

A study of 92 patients with multiple myeloma compared two-drug therapy (melphalan and prednisone) with five-drug combination therapy. Both treatments were effective in achieving remission, with similar survival rates. Maintenance treatment did not significantly affect relapse rates or survival.
Paper Details　
Original Abstract of the Article :
In a randomized study of 92 previously untreated patients with multiple myeloma, the intention was to document the possible beneficial effect of combination chemotherapy including vincristine, carmustine, alkylating agents and prednisone, as compared to conventional therapy with melphalan and predni...See full text at original site
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引用元：
https://doi.org/10.1111/j.1600-0609.1988.tb00867.x

データ提供：米国国立医学図書館（NLM）

Evaluating the Efficacy of Combination Chemotherapy for Multiple Myeloma

This research investigates the effectiveness of a 5-drug combination chemotherapy regimen compared to standard 2-drug therapy in patients with multiple myeloma. The study, conducted in central and northern Norway, involved 92 previously untreated patients randomly assigned to one of the two treatment groups. The results showed that both treatment regimens achieved similar remission rates and survival times. The authors conclude that the 5-drug combination therapy did not significantly improve survival compared to the 2-drug regimen, suggesting that standard therapy remains an effective treatment option for multiple myeloma.

Understanding Treatment Options for Multiple Myeloma

This research provides insights into the efficacy of different chemotherapy regimens for treating multiple myeloma. The study's findings suggest that the standard 2-drug regimen remains a viable and effective treatment option for this disease. The study emphasizes the importance of considering individual patient characteristics and risk factors when selecting the most appropriate treatment approach.

Navigating Treatment for Multiple Myeloma: A Collaborative Approach

This research highlights the importance of collaboration between healthcare professionals and patients in making informed decisions about treatment options for multiple myeloma. The study's findings underscore the need for a personalized approach that considers the unique characteristics of each patient.

Dr. Camel's Conclusion

This research reminds me of the enduring spirit of human resilience, even in the face of life-threatening illnesses. Just as desert nomads have honed their survival skills over centuries, medical professionals continue to develop and refine treatments for multiple myeloma. This study underscores the importance of ongoing research and clinical trials to improve patient outcomes and enhance the quality of life for those living with this disease.
Date :
  1. Date Completed 1988-09-15
  2. Date Revised 2019-09-08
Further Info :

Pubmed ID

3042453

DOI: Digital Object Identifier

10.1111/j.1600-0609.1988.tb00867.x

Related Literature

Article Analysis
・Effective treatment of multiple myeloma
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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