Dexlansoprazole and Esomeprazole Do Not Affect Bone Homeostasis in Healthy Postmenopausal Women.

Author: HansenKaren E, MetzDavid C, NievesJeri W, NudurupatiSai, PerezMaria Claudia

Paper Details 
Original Abstract of the Article :
Epidemiological studies have associated proton pump inhibitor (PPI) therapy with osteoporotic fractures, but it is not clear if PPIs directly cause osteoporosis. We evaluated the effect of dexlansoprazole and esomeprazole on bone turnover, bone mineral density (BMD), true fractional calcium absorpti...See full text at original site
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引用元:
https://doi.org/10.1053/j.gastro.2018.11.023

データ提供:米国国立医学図書館(NLM)

The Impact of Proton Pump Inhibitors on Bone Health

I’ve always been fascinated by the intricate dance of our bodies, especially the delicate balance of bone health. It’s like a delicate sandcastle on the shore of our digestive system, constantly being shaped by the forces of absorption and metabolism. This study dives into the intriguing world of proton pump inhibitors (PPIs), commonly used medications for heartburn and acid reflux. The researchers, like intrepid explorers in the desert of scientific discovery, used a rigorous approach to investigate the effects of dexlansoprazole and esomeprazole, two popular PPIs, on bone metabolism in postmenopausal women.

The Findings of a Bone-Building Expedition

The results, like a shimmering oasis in a vast desert, revealed that these PPIs, despite their widespread use, did not significantly affect bone turnover, mineral density, or calcium absorption in the study participants. This is an important finding, as previous research, like whispers in the desert wind, suggested a possible link between PPIs and osteoporosis. The researchers meticulously measured various markers of bone health, leaving no stone unturned in their quest for a conclusive answer.

The Significance for Bone Health and Beyond

This research is a beacon of hope for those who rely on PPIs for relief from digestive distress. It suggests that these medications, in the context of this study, are unlikely to negatively impact bone health. However, as with all scientific findings, it’s crucial to interpret these results within the broader context of individual patient needs and potential for variability. Remember, just like the desert landscape, our bodies are diverse, and what applies to one person may not apply to another.

Dr. Camel’s Conclusion

This study brings a much-needed clarity to the debate surrounding PPIs and bone health. It’s a reminder that our understanding of medicine is constantly evolving, and rigorous research, like a tireless camel trek, is essential for uncovering the secrets of our complex bodies. As with all medical decisions, it's crucial to consult with a healthcare professional to determine the best course of treatment tailored to your individual needs.
Date :
  1. Date Completed 2019-04-03
  2. Date Revised 2019-04-03
Further Info :

Pubmed ID

30445008

DOI: Digital Object Identifier

10.1053/j.gastro.2018.11.023

Related Literature

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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