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Novel Bruton tyrosine kinase inhibitor acalabrutinib quantification by validated LC-MS/MS method: An application to pharmacokinetic study in Sprague Dawley rats.
Author: ChoulwarSagar, DeshpandeAbhijeet, GiriSanjeev, PaulDavid, PokharkarSunil, SatheeshkumarN, SurendranShruti
Original Abstract of the Article :
USFDA has approved a novel Bruton tyrosine kinase (BTK) inhibitor acalabrutinib (ACA) for the treatment of mantle cell lymphoma in adults. ACA is more potent and selective with fewer side effects compared to other Bruton tyrosine kinase inhibitors. In the current work a highly sensitive, selective a...See full text at original site
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引用元：
https://doi.org/10.1016/j.jpba.2018.11.012
データ提供：米国国立医学図書館（NLM）
Novel Bruton tyrosine kinase inhibitor acalabrutinib quantification by validated LC-MS/MS method: An Application to pharmacokinetic study in Sprague Dawley rats.
This research focuses on developing and validating a new method for quantifying acalabrutinib, a promising drug for treating mantle cell lymphoma, a type of cancer. This research is like carefully crafting a new map for navigating the complex landscape of cancer treatment. The authors developed a sensitive and precise LC-MS/MS method to measure the levels of acalabrutinib in the blood of rats, providing valuable information for understanding how this drug works within the body.
What Does This Research Suggest?
This research provides a valuable tool for studying the pharmacokinetics of acalabrutinib, a novel Bruton tyrosine kinase inhibitor. The validated method allows researchers to precisely measure the drug's concentration in the bloodstream, providing crucial data for understanding how it is absorbed, distributed, metabolized, and eliminated by the body. This is like using a carefully calibrated compass to navigate the complex pathways of drug absorption and distribution within the body.
Implications for Your Health and Lifestyle
This research is an important step in developing safe and effective treatments for mantle cell lymphoma. By accurately measuring the levels of acalabrutinib in the body, researchers can optimize the drug's dosage and ensure its safe and effective delivery. It's like carefully choosing the right oasis to provide nourishment and sustenance to those battling this disease, ensuring that the journey towards healing is safe and successful.
Dr. Camel's Conclusion
The development of this validated LC-MS/MS method represents a significant advancement in the field of cancer research. It paves the way for more precise and effective treatment options for patients with mantle cell lymphoma, offering a beacon of hope in the fight against this challenging disease.
Date :
- Date Completed 2019-03-19
- Date Revised 2019-12-10
Further Info :
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