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Vincristine and prednisone prolong the survival of patients receiving intravenous or oral melphalan for multiple myeloma: Cancer and Leukemia Group B experience.
Author: BrunnerK, ColemanM, CooperM R, CornwellG G, GlowienkaL P, HendersonE, KochwaS, McIntyreO R, PajakT F, RaflaS
Original Abstract of the Article :
A total of 589 patients with previously untreated multiple myeloma were randomized to receive daily oral melphalan, pulse-dose intravenous (IV) melphalan, carmustine (BCNU), or lomustine (CCNU). All patients received an initial tapering course of prednisone (Pred). During week 22 (day 154), patients...See full text at original site
Dr.Camel's Paper Summary Blogラクダ博士について
ラクダ博士は、Health Journal が論文の内容を分かりやすく解説するために作成した架空のキャラクターです。
難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。
* ラクダ博士による解説は、あくまで論文の要点をまとめたものであり、原論文の完全な代替となるものではありません。詳細な内容については、必ず原論文をご参照ください。
* ラクダ博士は架空のキャラクターであり、実際の医学研究者や医療従事者とは一切関係がありません。
* 解説の内容は Health Journal が独自に解釈・作成したものであり、原論文の著者または出版社の見解を反映するものではありません。
引用元:
https://doi.org/10.1200/JCO.1988.6.9.1481
データ提供:米国国立医学図書館(NLM)
Combating Multiple Myeloma: A Battle in the Desert of Cancer
The battle against cancer is a vast and challenging desert, where researchers tirelessly seek effective weapons against this formidable foe. This study, like a strategic military campaign, investigates the impact of vincristine and prednisone on the survival of patients with multiple myeloma, a type of blood cancer. The researchers conducted a randomized clinical trial, comparing the effects of various treatment regimens on patient outcomes.
Vincristine and Prednisone: A Powerful Alliance in the Desert
The study found that the addition of vincristine and prednisone to melphalan therapy, a standard treatment for multiple myeloma, significantly prolonged survival, like a well-equipped caravan with additional provisions. This combination therapy was more effective in converting non-responders to responders, demonstrating its ability to overcome resistance and achieve better outcomes.
Hope for Multiple Myeloma Patients: A Glimpse of a Brighter Oasis
This research, like a well-traveled path through the desert, offers a glimmer of hope for patients with multiple myeloma. The findings highlight the effectiveness of a combination therapy approach, providing a potential path towards improved survival and quality of life.
Dr. Camel's Conclusion
This study, like a beacon in the desert, illuminates a promising avenue for treating multiple myeloma. The findings offer a new strategy for battling this formidable disease, bringing hope to patients and inspiring continued research efforts.
Date :
- Date Completed 1988-10-25
- Date Revised 2017-02-10
Further Info :
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