The effect of pasireotide on intestinal anastomotic healing with and without whole-body irradiation in a rat model.

Author: GlatzTorben, HoeppnerJens, HolznerPhilipp A, KirsteSimon, KulemannBirte, LaessleClaudia, LeitholdGunnar, MarjanovicGoran, SeifertGabriel J

Paper Details 
Original Abstract of the Article :
OBJECTIVE: To examine pasireotide's effect on intestinal anastomotic healing under physiological conditions and following preoperative whole-body irradiation. MATERIAL AND METHODS: Forty-five male Wistar rats received an ileoileal end-to-end anastomosis. Group 1 (Co, n = 9) served as control. Group...See full text at original site
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引用元:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6331742/

データ提供:米国国立医学図書館(NLM)

Pasireotide and Intestinal Anastomotic Healing: A Complex Interplay

Intestinal anastomotic healing is a crucial process following surgery. However, factors like whole-body irradiation can significantly impair this healing process. This study investigates the effect of pasireotide, a somatostatin analog, on intestinal anastomotic healing in a rat model, with and without whole-body irradiation. The study found that while pasireotide did not significantly improve anastomotic healing under physiological conditions, it did not worsen the negative effects of irradiation. The study underscores the complex interplay between pasireotide and irradiation on intestinal anastomotic healing, highlighting the need for further investigation to optimize postoperative care for irradiated patients.

A Desert of Challenges: Navigating the Intricacies of Intestinal Healing

This study delves into the complexities of intestinal anastomotic healing, particularly in the presence of whole-body irradiation. The researchers explored the potential of pasireotide, a somatostatin analog, to enhance healing in this challenging scenario. While the study did not reveal a significant positive effect of pasireotide on healing, it did not worsen the negative effects of irradiation, suggesting a potential role for this drug in managing the consequences of radiation exposure. Imagine a vast desert landscape, where each step is fraught with challenges. This study represents a journey through this desert, seeking to understand the intricate processes of intestinal healing and the role of pasireotide in navigating these challenges.

The Desert of Irradiation: Seeking Solutions for Intestinal Healing

This study provides valuable insights into the complex relationship between pasireotide, irradiation, and intestinal anastomotic healing. While the research did not show a significant positive effect of pasireotide on healing under irradiation, it did not worsen the negative effects of radiation exposure. This suggests that further research is needed to understand the potential role of pasireotide in optimizing postoperative care for irradiated patients. It's a journey through the desert of irradiation, where researchers are constantly seeking new ways to enhance healing and improve patient outcomes. This study serves as a stepping stone towards a better understanding of these complex interactions.

Dr.Camel's Conclusion

This study sheds light on the intricate interplay between pasireotide, irradiation, and intestinal anastomotic healing. While the research did not demonstrate a significant positive effect of pasireotide on healing, it underscores the importance of further investigation to understand its potential role in managing the consequences of radiation exposure. It's a journey through the desert of complex medical interactions, where researchers are constantly seeking new solutions to improve patient care and enhance healing.

Date :
  1. Date Completed 2019-04-29
  2. Date Revised 2020-02-25
Further Info :

Pubmed ID

30483864

DOI: Digital Object Identifier

PMC6331742

Related Literature

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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