Paper Details

  1. Home
  2. Paper Details

Treatment of actinic keratosis through inhibition of cyclooxygenase-2: Potential mechanism of action of diclofenac sodium 3% in hyaluronic acid 2.5.

Author: CruzSusana Balta, HerranzPedro, ParodiAurora, ThomasGareth J

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Overview

This study reviewed the role of COX-2/PGE2 pathway in tumorigenesis, particularly in cutaneous squamous cell carcinoma and actinic keratoses (AKs).
Paper Details　
Original Abstract of the Article :
Cyclooxygenase-2 (COX-2) and its metabolic product prostaglandin E<sub>2</sub> (PGE<sub>2</sub> ) are induced in response to growth factors, inflammatory cytokines, tumor promoters, activated oncogenes, and, in the skin, ultraviolet (UV) radiation. Accumulating evidence suggests a role for the COX-2...See full text at original site
Dr.Camel IconDr.Camel's Paper Summary Blogラクダ博士について

ラクダ博士は、Health Journal が論文の内容を分かりやすく解説するために作成した架空のキャラクターです。
難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。

* ラクダ博士による解説は、あくまで論文の要点をまとめたものであり、原論文の完全な代替となるものではありません。詳細な内容については、必ず原論文をご参照ください。
* ラクダ博士は架空のキャラクターであり、実際の医学研究者や医療従事者とは一切関係がありません。
* 解説の内容は Health Journal が独自に解釈・作成したものであり、原論文の著者または出版社の見解を反映するものではありません。


引用元：
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6767532/

データ提供：米国国立医学図書館（NLM）

Diclofenac Sodium: A Promising Treatment for Actinic Keratosis

Actinic keratosis (AK), a precancerous skin condition, is often caused by sun exposure. This article explores the potential of diclofenac sodium 3% in hyaluronic acid 2.5% as a treatment for AK, focusing on its mechanism of action in inhibiting cyclooxygenase-2 (COX-2) and its role in tumorigenesis.

Diclofenac Sodium: Targeting COX-2 for AK Treatment

The article discusses the role of COX-2 and its metabolic product prostaglandin E2 (PGE2) in the development of AK. It explains how diclofenac sodium, a nonsteroidal anti-inflammatory drug (NSAID), inhibits COX-2, potentially leading to the suppression of AK lesions.

Topical Treatments for Skin Cancer Prevention

This article highlights the potential of topical NSAIDs in preventing skin cancer. By understanding the mechanisms of action of these drugs, we can develop more effective and targeted treatments for precancerous skin conditions.

Dr. Camel's Conclusion

The sun's rays, while essential for life, can also be harmful. This research, like a desert traveler seeking shelter from the scorching sun, explores the potential of diclofenac sodium as a shield against the development of AK. By understanding the role of COX-2 in skin cancer, we can develop more effective strategies for preventing and treating this prevalent condition.

Date :
  1. Date Completed 2020-01-14
  2. Date Revised 2021-01-09
Further Info :

Pubmed ID

30523664

DOI: Digital Object Identifier

PMC6767532

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

This site uses cookies. Visit our privacy policy page or click the link in any footer for more information and to change your preferences.