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Influence of baseline neurologic severity on disease progression and the associated disease-modifying effects of tafamidis in patients with transthyretin amyloid polyneuropathy.
Author: AmassLeslie, GundapaneniBalarama K, KeohaneDenis J, LiHuihua, SchwartzJeffrey H
Original Abstract of the Article :
Emerging evidence suggests that several factors can impact disease progression in transthyretin amyloid polyneuropathy (ATTR-PN). The present analysis used longitudinal data from Val30Met patients participating in the tafamidis (selective TTR stabilizer) clinical development program to evaluate the ...See full text at original site
Dr.Camel's Paper Summary Blogラクダ博士について
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引用元:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6296038/
データ提供:米国国立医学図書館(NLM)
Influence of Baseline Neurologic Severity on Disease Progression and the Associated Disease-Modifying Effects of Tafamidis in Patients with Transthyretin Amyloid Polyneuropathy
The study of [transthyretin amyloid polyneuropathy (ATTR-PN)] focuses on understanding the progression of this debilitating disease and finding effective treatments. This analysis, utilizing [longitudinal data from patients participating in the tafamidis clinical development program], aimed to evaluate the impact of [baseline neurologic severity] on disease progression in ATTR-PN. The results suggest that [baseline neurologic severity] can influence disease progression, and [tafamidis] may have disease-modifying effects in patients with ATTR-PN.
Baseline Neurologic Severity and Disease Progression in ATTR-PN
The study's findings indicate that [patients with more severe neurologic impairment at baseline may experience a more rapid disease progression]. This highlights the importance of [early diagnosis and intervention] in ATTR-PN to potentially slow down disease progression.
The Promise of Tafamidis for ATTR-PN Treatment
The study also offers insights into the potential of [tafamidis] as a disease-modifying therapy for ATTR-PN. The results suggest that [tafamidis may slow down disease progression], although further research is needed to confirm these findings.
Dr.Camel's Conclusion
Just as a desert oasis can provide life-sustaining water, early diagnosis and treatment can help individuals with ATTR-PN manage their disease. This study underscores the importance of [understanding the impact of baseline severity] and exploring the potential of [disease-modifying therapies] like tafamidis to improve the lives of patients with ATTR-PN.
Date :
- Date Completed 2019-04-15
- Date Revised 2020-03-09
Further Info :
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