Paper Details

  1. Home
  2. Paper Details

Theanine attenuates memory impairments induced by klotho gene depletion in mice.

Author: JangChoon-Gon, JeongJi Hoon, KimHyoung-Chun, LeeSung Hoon, NabeshimaToshitaka, NahSeung-Yeol, NguyenBao Trong, SharmaNaveen, ShinEun-Joo, YonedaYukio

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

This study investigated the effects of theanine, an amino acid found in tea, on memory dysfunction in klotho mutant mice, a genetic aging model. Theanine significantly attenuated memory impairments by up-regulating JAK2/STAT3, M1 mAChR, and ERK signaling in the hippocampus.
Paper Details　
Original Abstract of the Article :
Theanine (γ-glutamylethylamide), an amino acid in tea, is a putative neuroprotective and antioxidant compound capable of improving lifespan and cognitive function. Because we previously reported cognitive dysfunction in klotho mutant mice via down-regulation of janus kinase 2 (JAK2) and signal trans...See full text at original site
Dr.Camel IconDr.Camel's Paper Summary Blogラクダ博士について

ラクダ博士は、Health Journal が論文の内容を分かりやすく解説するために作成した架空のキャラクターです。
難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。

* ラクダ博士による解説は、あくまで論文の要点をまとめたものであり、原論文の完全な代替となるものではありません。詳細な内容については、必ず原論文をご参照ください。
* ラクダ博士は架空のキャラクターであり、実際の医学研究者や医療従事者とは一切関係がありません。
* 解説の内容は Health Journal が独自に解釈・作成したものであり、原論文の著者または出版社の見解を反映するものではありません。


引用元：
https://doi.org/10.1039/c8fo01577e

データ提供：米国国立医学図書館（NLM）

Theanine: A Potential Hope for Memory in Aging?

Theanine, an amino acid found in tea, is known for its potential neuroprotective benefits. This study investigates the ability of theanine to attenuate memory impairments in mice with klotho gene depletion, a model of accelerated aging.

The researchers found that theanine administration significantly attenuated memory impairments in klotho mutant mice. This effect was linked to theanine's ability to upregulate the JAK2/STAT3, M1 mAChR, and ERK signaling pathways in the hippocampus, a brain region crucial for memory function.

Theanine: A Potential Oasis in the Desert of Memory Loss

This study suggests that theanine could potentially play a role in preserving cognitive function as we age. It's like finding a hidden oasis in the vast desert of memory loss – theanine could be a valuable tool for maintaining mental sharpness.

Theanine: A Tea-Infused Boost for Brain Health

This research is like a camel caravan discovering a new, and potentially beneficial, tea blend – it offers a promising glimpse into the potential of theanine for enhancing cognitive function.

Dr. Camel's Conclusion

This study is like a camel caravan discovering a new source of fresh water in the desert – theanine offers a potential avenue for improving cognitive function and preserving memory as we age.

Date :
  1. Date Completed 2019-04-09
  2. Date Revised 2021-12-04
Further Info :

Pubmed ID

30574980

DOI: Digital Object Identifier

10.1039/c8fo01577e

Related Literature

Article Analysis
・Effects of dicyclomine
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

This site uses cookies. Visit our privacy policy page or click the link in any footer for more information and to change your preferences.