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Phase 2, randomized dose-finding study of tapinarof (GSK2894512 cream) for the treatment of plaque psoriasis.

Author: BissonnetteRobert, GallagherKelly, KrausJohn E, Maeda-ChubachiTomoko, PeppersJohnny, RobbinsKevin, YeLi

Clinical Trial, Phase IIA Phase II trial is a trial that further evaluates the efficacy and safety of a new drug or treatment, whose safety has been confirmed to some extent in a Phase I trial, in a small number of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Overview

Tapinarof cream was found to be efficacious and well tolerated in adult patients with psoriasis. The study found that treatment success defined by PGA 0 or 1 and a 2-grade improvement at week 12 was statistically significantly higher in the tapinarof groups compared to vehicle groups.
Paper Details　
Original Abstract of the Article :
BACKGROUND: There is a significant need for novel, safe, and efficacious topical treatments for psoriasis. OBJECTIVE: We assessed the safety and efficacy of tapinarof in a new cream formulation at 2 concentrations and with 2 application frequencies in adults with psoriasis. METHODS: Double-blind, ...See full text at original site
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引用元：
https://doi.org/10.1016/j.jaad.2018.10.037

データ提供：米国国立医学図書館（NLM）

Tapinarof: A Promising New Treatment for Plaque Psoriasis

This study investigates the efficacy and safety of tapinarof, a novel topical treatment for plaque psoriasis, a common inflammatory skin condition. The researchers conducted a randomized controlled trial comparing different concentrations and application frequencies of tapinarof cream to a placebo in adults with plaque psoriasis. The study found that tapinarof cream significantly improved psoriasis symptoms, leading to a significant reduction in the severity and extent of skin lesions. The study also found that tapinarof was generally well tolerated, with most side effects being mild to moderate in severity.

Tapinarof: A New Hope for Psoriasis Patients

The study's findings provide compelling evidence for the effectiveness of tapinarof as a topical treatment for plaque psoriasis. The drug's ability to significantly improve symptoms and its favorable safety profile make it a promising new option for patients seeking relief from this chronic skin condition.

Living with Psoriasis: Managing Symptoms and Seeking Effective Treatments

This study underscores the importance of seeking appropriate medical care for psoriasis. Effective treatments like tapinarof can significantly improve quality of life for individuals living with this chronic condition. The study highlights the ongoing efforts to develop new and better treatments for psoriasis, offering hope for a more comfortable and fulfilling life for those affected.

Dr. Camel's Conclusion

This study is like a refreshing oasis in the vast desert of psoriasis research, offering a new and promising treatment option for patients struggling with this chronic condition. Tapinarof emerges as a potential oasis, providing relief from the discomfort and limitations of psoriasis, offering hope for a brighter future for those affected.

Date :
  1. Date Completed 2019-03-25
  2. Date Revised 2019-04-09
Further Info :

Pubmed ID

30612986

DOI: Digital Object Identifier

10.1016/j.jaad.2018.10.037

Related Literature

Article Analysis
・Effective treatment of psoriasis
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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